Assay Detail
Binding
CHEMBL4433394
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Inhibition of HO-1 in Sprague-Dawley rat spleen microsomes using NADPH as substrate incubated for 60 mins by spectrometry based assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Spleen |
| Subcellular | Microsomes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Progress in the development of selective heme oxygenase-1 inhibitors and their potential therapeutic application.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.85 | 5.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL482686 | — | — | 1 | 5.68 |
| CHEMBL2298629 | — | — | 1 | 5.60 |
| CHEMBL4589369 | — | — | 1 | 5.04 |
| CHEMBL484291 | — | — | 1 | 5.00 |
| CHEMBL1190440 | — | — | 1 | 5.00 |
| CHEMBL284827 | — | — | 1 | 4.55 |
| CHEMBL4534531 | — | — | 1 | 4.54 |
| CHEMBL4459358 | — | — | 1 | 4.17 |
| CHEMBL4538246 | — | — | 1 | 4.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL482686 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL2298629 | — | IC50 | = | 2500.0 | nM | 5.60 |
| CHEMBL4589369 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL484291 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL1190440 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL284827 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL4534531 | — | IC50 | = | 28800.0 | nM | 4.54 |
| CHEMBL4459358 | — | IC50 | = | 67600.0 | nM | 4.17 |
| CHEMBL4538246 | — | IC50 | = | 80000.0 | nM | 4.10 |