Assay Detail
Binding
CHEMBL4433402
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human serum butyrylcholinesterase using BTCI as substrate pre-incubated for 10 mins followed by substrate addition and measured for 6 mins by Ellman's method
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and development of multitarget-directed N-Benzylpiperidine analogs as potential candidates for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.24 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | 5.96 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 5.85 |
| CHEMBL4583534 | — | — | 1 | 5.52 |
| CHEMBL4443695 | — | — | 1 | 5.51 |
| CHEMBL4587156 | — | — | 1 | 5.46 |
| CHEMBL4091169 | — | — | 1 | 5.46 |
| CHEMBL4575167 | — | — | 1 | 5.41 |
| CHEMBL1424080 | — | — | 1 | 5.41 |
| CHEMBL1348834 | — | — | 1 | 5.40 |
| CHEMBL4526950 | — | — | 1 | 5.34 |
| CHEMBL4449445 | — | — | 1 | 5.26 |
| CHEMBL4568264 | — | — | 1 | 5.24 |
| CHEMBL4435826 | — | — | 1 | 5.14 |
| CHEMBL4452092 | — | — | 1 | 5.14 |
| CHEMBL4442580 | — | — | 1 | 5.11 |
| CHEMBL4591283 | — | — | 1 | 4.96 |
| CHEMBL4440283 | — | — | 1 | 4.96 |
| CHEMBL4453051 | — | — | 1 | 4.92 |
| CHEMBL4447514 | — | — | 1 | 4.85 |
| CHEMBL4467620 | — | — | 1 | 4.80 |
| CHEMBL4443013 | — | — | 1 | 4.75 |
| CHEMBL4556855 | — | — | 1 | 4.72 |
| CHEMBL4566555 | — | — | 1 | - |
| CHEMBL4444849 | — | — | 1 | - |
| CHEMBL4537808 | — | — | 1 | - |
| CHEMBL4454571 | — | — | 1 | - |
| CHEMBL4566242 | — | — | 1 | - |
| CHEMBL4518938 | — | — | 1 | - |
| CHEMBL4568615 | — | — | 1 | - |
| CHEMBL4561792 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL636 | RIVASTIGMINE | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4583534 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL4443695 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4587156 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4091169 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4575167 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1424080 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL1348834 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4526950 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4449445 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4568264 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4435826 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4452092 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4442580 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4440283 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4591283 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL4453051 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL4447514 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL4467620 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL4443013 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL4556855 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL4566555 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4444849 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4537808 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4454571 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4566242 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4518938 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4568615 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4561792 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4458653 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4444968 | — | IC50 | > | 30000.0 | nM | - |