Assay Detail
Binding
CHEMBL4433439
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Inhibition of mouse brain AChE using acetylthiocholine iodide as substrate measured after 30 mins by Ellman's method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, and evaluation of isoflavone analogs as multifunctional agents for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.82 | 7.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4568293 | — | — | 1 | 7.09 |
| CHEMBL502 | DONEPEZIL | 4.0 | 1 | 7.08 |
| CHEMBL4552051 | — | — | 1 | 6.70 |
| CHEMBL4554072 | — | — | 1 | 6.46 |
| CHEMBL4586884 | — | — | 1 | 6.15 |
| CHEMBL4438929 | — | — | 1 | 6.02 |
| CHEMBL4439461 | — | — | 1 | 5.40 |
| CHEMBL4471251 | — | — | 1 | 5.35 |
| CHEMBL4450260 | — | — | 1 | 5.30 |
| CHEMBL4554976 | — | — | 1 | 5.02 |
| CHEMBL4516496 | — | — | 1 | 4.65 |
| CHEMBL4555824 | — | — | 1 | 4.57 |
| CHEMBL4583406 | — | — | 1 | - |
| CHEMBL4445115 | — | — | 1 | - |
| CHEMBL4476554 | — | — | 1 | - |
| CHEMBL4543223 | — | — | 1 | - |
| CHEMBL260374 | THIOPERAMIDE | — | 1 | - |
| CHEMBL636 | RIVASTIGMINE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4568293 | — | IC50 | = | 81.0 | nM | 7.09 |
| CHEMBL502 | DONEPEZIL | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL4552051 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4554072 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4586884 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL4438929 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL4439461 | — | IC50 | = | 3980.0 | nM | 5.40 |
| CHEMBL4471251 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4450260 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4554976 | — | IC50 | = | 9470.0 | nM | 5.02 |
| CHEMBL4516496 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL4555824 | — | IC50 | = | 26790.0 | nM | 4.57 |
| CHEMBL4583406 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4445115 | — | IC50 | - | — | - | |
| CHEMBL4476554 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4543223 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL260374 | THIOPERAMIDE | IC50 | - | — | - | |
| CHEMBL636 | RIVASTIGMINE | IC50 | - | — | - |