Assay Detail
Binding
CHEMBL4433652
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Inhibition of human recombinant GSK3beta using GSM as substrate incubated for 30 mins by luminescence based assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of the First-in-Class GSK-3β/HDAC Dual Inhibitor as Disease-Modifying Agent To Combat Alzheimer's Disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.44 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322970 | — | — | 1 | 7.30 |
| CHEMBL4449010 | — | — | 1 | 5.57 |
| CHEMBL4575045 | — | — | 1 | 5.39 |
| CHEMBL4590543 | — | — | 1 | 5.01 |
| CHEMBL4443876 | — | — | 1 | 4.70 |
| CHEMBL277294 | PHTHALIMIDE | — | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322970 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4449010 | — | IC50 | = | 2690.0 | nM | 5.57 |
| CHEMBL4575045 | — | IC50 | = | 4110.0 | nM | 5.39 |
| CHEMBL4590543 | — | IC50 | = | 9850.0 | nM | 5.01 |
| CHEMBL4443876 | — | IC50 | = | 19960.0 | nM | 4.70 |
| CHEMBL277294 | PHTHALIMIDE | IC50 | = | 20220.0 | nM | 4.69 |