Compound Detail
CHEMBL277294
PHTHALIMIDE Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL277294 |
| Name | PHTHALIMIDE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XKJCHHZQLQNZHY-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
16
Publications
0
Known Names
Molecular Properties
147.1
MW (Da)
0.57
ALogP
2
HBA
1
HBD
46.2
PSA (Ų)
0.55
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 4.69
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glycogen synthase kinase-3 beta CHEMBL262 | IC50 | 4.69 | 4.69 | 20220.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glycogen synthase kinase-3 beta | IC50 | = | 20220.0 | nM | 4.69 | Inhibition of human recombinant GSK3beta using GSM as substrate incubated for 30... | 30996781 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30996781 | 10.1021/acsmedchemlett.8b00507 | SH-SY5Y | 5 |
| 6737419 | 10.1021/jm00372a011 | Mus musculus | 3 |
| 6131131 | 10.1021/jm00356a022 | Mus musculus | 3 |
| 6827542 | 10.1021/jm00356a023 | Mus musculus | 3 |
| 3965717 | 10.1021/jm00379a003 | Mus musculus | 3 |
| 30996781 | 10.1021/acsmedchemlett.8b00507 | Microglia | 3 |
| 17378546 | 10.1021/jm061471k | Unchecked | 2 |
| 30996781 | 10.1021/acsmedchemlett.8b00507 | Glycogen synthase kinase-3 beta | 2 |
| 12873507 | 10.1016/s0960-894x(03)00535-3 | Unchecked | 1 |
| 17378546 | 10.1021/jm061471k | Liver carboxylesterase 1 | 1 |
| 21778064 | 10.1016/j.bmc.2011.06.070 | Amine oxidase [flavin-containing] A | 1 |
| 21778064 | 10.1016/j.bmc.2011.06.070 | Amine oxidase [flavin-containing] B | 1 |
| 30996781 | 10.1021/acsmedchemlett.8b00507 | Histone deacetylase 1 | 1 |
| 30996781 | 10.1021/acsmedchemlett.8b00507 | Histone deacetylase 6 | 1 |
| 30996781 | 10.1021/acsmedchemlett.8b00507 | Histone deacetylase | 1 |
| 30996781 | 10.1021/acsmedchemlett.8b00507 | Cerebellar granule neurone | 1 |
Data from ChEMBL 36 via Core Engine