Assay Detail
Binding
CHEMBL4433965
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Agonist activity at wild type human D1R expressed in HEK293 cells assessed as effect on beta-arrestin2 recruitment by PRESTO-Tango beta-arrestin2 recruitment assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 6.42 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4453318 | — | — | 1 | 7.46 |
| CHEMBL4277264 | — | — | 1 | 6.50 |
| CHEMBL353335 | — | — | 1 | 6.44 |
| CHEMBL4469983 | — | — | 1 | 6.31 |
| CHEMBL4437012 | — | — | 1 | 5.96 |
| CHEMBL59 | DOPAMINE | 4.0 | 1 | 5.85 |
| CHEMBL3697578 | RAZPIPADON | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4453318 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4277264 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL353335 | — | EC50 | = | 360.0 | nM | 6.44 |
| CHEMBL4469983 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4437012 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL59 | DOPAMINE | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL3697578 | RAZPIPADON | EC50 | - | — | - |