Assay Detail
Binding
CHEMBL4433967
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-SCH23390 from wild type human D1R expressed in HEK293 cell membranes incubated for 90 mins by scintillation counting based competition radioligand binding assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Pharmacological Evaluation of Noncatechol G Protein Biased and Unbiased Dopamine D1 Receptor Agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.76 | 8.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4453318 | — | — | 1 | 8.62 |
| CHEMBL353335 | — | — | 1 | 7.82 |
| CHEMBL4469983 | — | — | 1 | 7.29 |
| CHEMBL3697578 | RAZPIPADON | 2.0 | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4453318 | — | Ki | = | 2.4 | nM | 8.62 |
| CHEMBL353335 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL4469983 | — | Ki | = | 51.0 | nM | 7.29 |
| CHEMBL3697578 | RAZPIPADON | Ki | = | 51.0 | nM | 7.29 |