Assay Detail
Binding
CHEMBL4434178
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Inhibition of FLAG-tagged CDK14 (unknown origin) expressed in human HEK293 cells assessed as blocking of CDK14 pulldown incubated for 4 hrs by biotinylated JNK-IN- based pull down assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and structure activity relationships of a series of 4-amino-1H-pyrazoles as covalent inhibitors of CDK14.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.40 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4522598 | — | — | 1 | 7.30 |
| CHEMBL4542127 | — | — | 1 | 7.30 |
| CHEMBL4554744 | — | — | 1 | 6.30 |
| CHEMBL4534124 | — | — | 1 | 6.30 |
| CHEMBL4522564 | — | — | 1 | 6.00 |
| CHEMBL4555069 | — | — | 1 | 6.00 |
| CHEMBL4589122 | — | — | 1 | 6.00 |
| CHEMBL4530961 | — | — | 1 | 6.00 |
| CHEMBL4456492 | — | — | 1 | - |
| CHEMBL4584359 | — | — | 1 | - |
| CHEMBL4466865 | — | — | 1 | - |
| CHEMBL4464758 | — | — | 1 | - |
| CHEMBL4434727 | — | — | 1 | - |
| CHEMBL4544087 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4522598 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4542127 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4554744 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4534124 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4522564 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4555069 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4589122 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4530961 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4456492 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4584359 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4466865 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4464758 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL4434727 | — | IC50 | >= | 500.0 | nM | - |
| CHEMBL4544087 | — | IC50 | > | 1000.0 | nM | - |