Assay Detail
Binding
CHEMBL4434583
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PDL1 expressed in CHO-K1 cells co-expressing aAPC assessed as reduction in PDL1 interaction with human PD1 expressed in Jurkat T cells incubated for 18 hrs by Bio-Glo reagent based luminescence assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Target
Programmed cell death protein 1/Programmed cell death 1 ligand 1 (CHEMBL4523993) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Symmetry-based ligand design and evaluation of small molecule inhibitors of programmed cell death-1/programmed death-ligand 1 interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 7 | 5.37 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4473436 | — | — | 1 | 6.00 |
| CHEMBL4456990 | — | — | 1 | 5.08 |
| CHEMBL4578475 | — | — | 1 | 5.02 |
| CHEMBL4473243 | — | — | 1 | - |
| CHEMBL4515820 | — | — | 1 | - |
| CHEMBL4472332 | — | — | 1 | - |
| CHEMBL4460716 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4473436 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL4456990 | — | EC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4578475 | — | EC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL4473243 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL4515820 | — | EC50 | - | — | - | |
| CHEMBL4472332 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL4460716 | — | EC50 | - | — | - |