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Assay Detail

CHEMBL4476912

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Binding
Inhibition of human c-Myc assessed as reduction in c-Myc/Max/Ebox DNA complex formation using pre-formed complex of c-Myc and biotinylated DNA containing single Ebox-sequence followed by compound addition and further addition of his6-tagged c-Max and incubated for 2 hrs by AlphaScreen assay
ChEMBL ↗
185
Total Activities
185
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Myc proto-oncogene protein (CHEMBL1250348) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Pyrrol-1-yl benzoic acid derivatives useful as myc inhibitors
(2015)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 185 5.08 6.54

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4541510 — — 1 6.54
CHEMBL4560523 — — 1 6.46
CHEMBL4575537 — — 1 6.41
CHEMBL4514651 — — 1 6.38
CHEMBL4524924 — — 1 6.32
CHEMBL4521116 — — 1 6.31
CHEMBL4534756 — — 1 6.28
CHEMBL4560633 — — 1 6.27
CHEMBL4592328 — — 1 6.17
CHEMBL4580673 — — 1 6.15
CHEMBL4518419 — — 1 6.10
CHEMBL4526765 — — 1 6.00
CHEMBL4584727 — — 1 6.00
CHEMBL4555437 — — 1 6.00
CHEMBL4551916 — — 1 6.00
CHEMBL4526749 — — 1 6.00
CHEMBL4514773 — — 1 6.00
CHEMBL4564656 — — 1 6.00
CHEMBL4483581 — — 1 6.00
CHEMBL4575641 — — 1 6.00
CHEMBL4588981 — — 1 6.00
CHEMBL4562506 — — 1 6.00
CHEMBL4580970 — — 1 6.00
CHEMBL4534386 — — 1 6.00
CHEMBL4562662 — — 1 5.90
CHEMBL505875 — — 1 5.81
CHEMBL4588527 — — 1 5.78
CHEMBL4571842 — — 1 5.76
CHEMBL4589104 — — 1 5.75
CHEMBL4562525 — — 1 5.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4541510 — IC50 = 291.0 nM 6.54
CHEMBL4560523 — IC50 = 343.0 nM 6.46
CHEMBL4575537 — IC50 = 393.0 nM 6.41
CHEMBL4514651 — IC50 = 420.0 nM 6.38
CHEMBL4524924 — IC50 = 480.0 nM 6.32
CHEMBL4521116 — IC50 = 492.0 nM 6.31
CHEMBL4534756 — IC50 = 531.0 nM 6.28
CHEMBL4560633 — IC50 = 534.0 nM 6.27
CHEMBL4592328 — IC50 = 675.0 nM 6.17
CHEMBL4580673 — IC50 = 708.0 nM 6.15
CHEMBL4518419 — IC50 = 788.0 nM 6.10
CHEMBL4562506 — IC50 = 1000.0 nM 6.00
CHEMBL4555437 — IC50 = 1000.0 nM 6.00
CHEMBL4584727 — IC50 = 1000.0 nM 6.00
CHEMBL4551916 — IC50 = 1000.0 nM 6.00
CHEMBL4514773 — IC50 = 1000.0 nM 6.00
CHEMBL4564656 — IC50 = 1000.0 nM 6.00
CHEMBL4483581 — IC50 = 1000.0 nM 6.00
CHEMBL4575641 — IC50 = 1000.0 nM 6.00
CHEMBL4526749 — IC50 = 1000.0 nM 6.00
CHEMBL4588981 — IC50 = 1000.0 nM 6.00
CHEMBL4580970 — IC50 = 1000.0 nM 6.00
CHEMBL4534386 — IC50 = 1000.0 nM 6.00
CHEMBL4526765 — IC50 = 1000.0 nM 6.00
CHEMBL4562662 — IC50 = 1250.0 nM 5.90
CHEMBL505875 — IC50 = 1540.0 nM 5.81
CHEMBL4588527 — IC50 = 1660.0 nM 5.78
CHEMBL4571842 — IC50 = 1750.0 nM 5.76
CHEMBL4589104 — IC50 = 1800.0 nM 5.75
CHEMBL4562525 — IC50 = 1890.0 nM 5.72
CHEMBL4520603 — IC50 = 2720.0 nM 5.57
CHEMBL4550118 — IC50 = 2970.0 nM 5.53
CHEMBL4538921 — IC50 = 2950.0 nM 5.53
CHEMBL4531825 — IC50 = 3840.0 nM 5.42
CHEMBL4551980 — IC50 = 3990.0 nM 5.40
CHEMBL212723 — IC50 = 4290.0 nM 5.37
CHEMBL4584499 — IC50 = 4820.0 nM 5.32
CHEMBL4586997 — IC50 = 4880.0 nM 5.31
CHEMBL4564509 — IC50 = 5550.0 nM 5.26
CHEMBL4540324 — IC50 = 5560.0 nM 5.25
CHEMBL4580874 — IC50 = 5970.0 nM 5.22
CHEMBL4560920 — IC50 = 6520.0 nM 5.19
CHEMBL4566915 — IC50 = 6850.0 nM 5.16
CHEMBL4565626 — IC50 = 7050.0 nM 5.15
CHEMBL4544077 — IC50 = 7110.0 nM 5.15
CHEMBL4538417 — IC50 = 7270.0 nM 5.14
CHEMBL4534256 — IC50 = 7670.0 nM 5.12
CHEMBL4536775 — IC50 = 7690.0 nM 5.11
CHEMBL4560643 — IC50 = 8580.0 nM 5.07
CHEMBL4533461 — IC50 = 9300.0 nM 5.03