Assay Detail
Binding
CHEMBL4476942
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant full length C-Myc/DDK-tagged human SYNJ2 expressed in HEK293T cells using PI(3,4,5)P3 as substrate incubated for 8 mins assessed as hydrolysis of PI(3,4,5)P3 to PI(3,4)P2 by fluorescence polarization assay
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Methods of preventing tumor metastasis, treating and prognosing cancer and identifying agents which are putative metastasis inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.50 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL509624 | — | — | 1 | 6.06 |
| CHEMBL4472624 | — | — | 1 | 5.97 |
| CHEMBL4457836 | — | — | 1 | 5.91 |
| CHEMBL1201303 | PYRVINIUM | 4.0 | 1 | 5.90 |
| CHEMBL4514986 | — | — | 1 | 5.78 |
| CHEMBL4574176 | — | — | 1 | 5.73 |
| CHEMBL4575159 | — | — | 1 | 5.70 |
| CHEMBL4577306 | — | — | 1 | 5.66 |
| CHEMBL4451084 | — | — | 1 | 5.57 |
| CHEMBL452764 | — | — | 1 | 5.55 |
| CHEMBL36327 | EPICATECHIN GALLATE | — | 1 | 5.54 |
| CHEMBL3236511 | — | — | 1 | 5.53 |
| CHEMBL3348861 | AMPELOPSIN | 2.0 | 1 | 5.50 |
| CHEMBL4437511 | — | — | 1 | 5.50 |
| CHEMBL4536358 | — | — | 1 | 5.47 |
| CHEMBL4471702 | — | — | 1 | 5.46 |
| CHEMBL4551186 | — | — | 1 | 5.45 |
| CHEMBL84333 | — | — | 1 | 5.43 |
| CHEMBL4590432 | — | — | 1 | 5.22 |
| CHEMBL43065 | OXYRESVERATROL | — | 1 | 5.18 |
| CHEMBL522251 | — | — | 1 | 5.12 |
| CHEMBL790 | CHLORHEXIDINE | 4.0 | 1 | 5.00 |
| CHEMBL4538767 | — | — | 1 | 4.99 |
| CHEMBL159303 | EPIAFZELECHIN (2R,3R)(-) | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL509624 | — | IC50 | = | 874.0 | nM | 6.06 |
| CHEMBL4472624 | — | IC50 | = | 1075.0 | nM | 5.97 |
| CHEMBL4457836 | — | IC50 | = | 1240.0 | nM | 5.91 |
| CHEMBL1201303 | PYRVINIUM | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL4514986 | — | IC50 | = | 1670.0 | nM | 5.78 |
| CHEMBL4574176 | — | IC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL4575159 | — | IC50 | = | 1980.0 | nM | 5.70 |
| CHEMBL4577306 | — | IC50 | = | 2190.0 | nM | 5.66 |
| CHEMBL4451084 | — | IC50 | = | 2710.0 | nM | 5.57 |
| CHEMBL452764 | — | IC50 | = | 2840.0 | nM | 5.55 |
| CHEMBL36327 | EPICATECHIN GALLATE | IC50 | = | 2880.0 | nM | 5.54 |
| CHEMBL3236511 | — | IC50 | = | 2940.0 | nM | 5.53 |
| CHEMBL3348861 | AMPELOPSIN | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL4437511 | — | IC50 | = | 3170.0 | nM | 5.50 |
| CHEMBL4536358 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4471702 | — | IC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL4551186 | — | IC50 | = | 3520.0 | nM | 5.45 |
| CHEMBL84333 | — | IC50 | = | 3750.0 | nM | 5.43 |
| CHEMBL4590432 | — | IC50 | = | 6020.0 | nM | 5.22 |
| CHEMBL43065 | OXYRESVERATROL | IC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL522251 | — | IC50 | = | 7530.0 | nM | 5.12 |
| CHEMBL790 | CHLORHEXIDINE | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4538767 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL159303 | EPIAFZELECHIN (2R,3R)(-) | IC50 | = | 15900.0 | nM | 4.80 |