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Assay Detail

CHEMBL4476981

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of recombinant His6-tagged MAT2A (unknown origin) expressed in SF9 insect cells using L-Met as substrate preincubated for 60 mins followed by substrate and ATP addition and measured after 60 mins by spectrophotometric analysis
ChEMBL ↗
246
Total Activities
246
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type Sf9
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

S-adenosylmethionine synthase isoform type-2 (CHEMBL3313835) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibitors of cellular metabolic processes
(2018)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 246 6.64 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4572719 — — 1 7.00
CHEMBL4546271 — — 1 7.00
CHEMBL4483341 — — 1 7.00
CHEMBL4567243 — — 1 7.00
CHEMBL4553872 — — 1 7.00
CHEMBL4555060 — — 1 7.00
CHEMBL4573526 — — 1 7.00
CHEMBL4573728 — — 1 7.00
CHEMBL4551093 — — 1 7.00
CHEMBL4522257 — — 1 7.00
CHEMBL4538283 — — 1 7.00
CHEMBL4580282 — — 1 7.00
CHEMBL4588181 — — 1 7.00
CHEMBL4521225 — — 1 7.00
CHEMBL4546944 — — 1 7.00
CHEMBL4571843 — — 1 7.00
CHEMBL4527123 — — 1 7.00
CHEMBL4568510 — — 1 7.00
CHEMBL4583730 — — 1 7.00
CHEMBL4561105 — — 1 7.00
CHEMBL4514719 — — 1 7.00
CHEMBL4569602 — — 1 7.00
CHEMBL4562374 — — 1 7.00
CHEMBL4542083 — — 1 7.00
CHEMBL4567650 — — 1 7.00
CHEMBL4525301 — — 1 7.00
CHEMBL4561650 — — 1 7.00
CHEMBL4527921 — — 1 7.00
CHEMBL4546633 — — 1 7.00
CHEMBL4522713 — — 1 7.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4588181 — IC50 = 100.0 nM 7.00
CHEMBL4573526 — IC50 = 100.0 nM 7.00
CHEMBL4573728 — IC50 = 100.0 nM 7.00
CHEMBL4551093 — IC50 = 100.0 nM 7.00
CHEMBL4562374 — IC50 = 100.0 nM 7.00
CHEMBL4522257 — IC50 = 100.0 nM 7.00
CHEMBL4538283 — IC50 = 100.0 nM 7.00
CHEMBL4569602 — IC50 = 100.0 nM 7.00
CHEMBL4580282 — IC50 = 100.0 nM 7.00
CHEMBL4571843 — IC50 = 100.0 nM 7.00
CHEMBL4521225 — IC50 = 100.0 nM 7.00
CHEMBL4546944 — IC50 = 100.0 nM 7.00
CHEMBL4572719 — IC50 = 100.0 nM 7.00
CHEMBL4527123 — IC50 = 100.0 nM 7.00
CHEMBL4568510 — IC50 = 100.0 nM 7.00
CHEMBL4583730 — IC50 = 100.0 nM 7.00
CHEMBL4561105 — IC50 = 100.0 nM 7.00
CHEMBL4514719 — IC50 = 100.0 nM 7.00
CHEMBL4553872 — IC50 = 100.0 nM 7.00
CHEMBL4530602 — IC50 = 100.0 nM 7.00
CHEMBL4522713 — IC50 = 100.0 nM 7.00
CHEMBL4546633 — IC50 = 100.0 nM 7.00
CHEMBL4527921 — IC50 = 100.0 nM 7.00
CHEMBL4561650 — IC50 = 100.0 nM 7.00
CHEMBL4525301 — IC50 = 100.0 nM 7.00
CHEMBL4567650 — IC50 = 100.0 nM 7.00
CHEMBL4542083 — IC50 = 100.0 nM 7.00
CHEMBL4558233 — IC50 = 100.0 nM 7.00
CHEMBL4576190 — IC50 = 100.0 nM 7.00
CHEMBL4578643 — IC50 = 100.0 nM 7.00
CHEMBL4516541 — IC50 = 100.0 nM 7.00
CHEMBL4546271 — IC50 = 100.0 nM 7.00
CHEMBL4483341 — IC50 = 100.0 nM 7.00
CHEMBL4567243 — IC50 = 100.0 nM 7.00
CHEMBL4555060 — IC50 = 100.0 nM 7.00
CHEMBL4568635 — IC50 = 100.0 nM 7.00
CHEMBL4539716 — IC50 = 1000.0 nM 6.00
CHEMBL4552902 — IC50 = 1000.0 nM 6.00
CHEMBL4545746 — IC50 = 1000.0 nM 6.00
CHEMBL4557822 — IC50 = 1000.0 nM 6.00
CHEMBL4546541 — IC50 = 1000.0 nM 6.00
CHEMBL4589253 — IC50 = 1000.0 nM 6.00
CHEMBL4543000 — IC50 = 1000.0 nM 6.00
CHEMBL4535134 — IC50 = 1000.0 nM 6.00
CHEMBL4531472 — IC50 = 1000.0 nM 6.00
CHEMBL4530824 — IC50 = 1000.0 nM 6.00
CHEMBL4536984 — IC50 = 1000.0 nM 6.00
CHEMBL4521572 — IC50 = 1000.0 nM 6.00
CHEMBL4518014 — IC50 = 1000.0 nM 6.00
CHEMBL4581059 — IC50 = 1000.0 nM 6.00