Assay Detail
Binding
CHEMBL4476983
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of ADEP2591 from Staphylococcus aureus ClpP expressed in Escherichia coli BL21 (DE3) incubated for 120 mins by fluorescence polarization assay
54
Total Activities
54
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Staphylococcus aureus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
ATP-dependent Clp protease proteolytic subunit (CHEMBL1932910) ↗| Type | SINGLE PROTEIN |
| Organism | Staphylococcus aureus (strain NCTC 8325) |
Publication
Substituted urea depsipeptide analogs as activators of the clpp endopeptidase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 54 | 5.08 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4591519 | — | — | 1 | 5.40 |
| CHEMBL4520667 | — | — | 1 | 5.35 |
| CHEMBL4553929 | — | — | 1 | 5.34 |
| CHEMBL4530326 | — | — | 1 | 5.31 |
| CHEMBL3764224 | — | — | 1 | 5.28 |
| CHEMBL4537982 | — | — | 1 | 5.25 |
| CHEMBL4528556 | — | — | 1 | 5.25 |
| CHEMBL4579446 | — | — | 1 | 5.25 |
| CHEMBL4518765 | — | — | 1 | 5.25 |
| CHEMBL4562037 | — | — | 1 | 5.24 |
| CHEMBL4536809 | — | — | 1 | 5.24 |
| CHEMBL4536651 | — | — | 1 | 5.23 |
| CHEMBL4528926 | — | — | 1 | 5.22 |
| CHEMBL3765324 | — | — | 1 | 5.21 |
| CHEMBL4536048 | — | — | 1 | 5.21 |
| CHEMBL4561696 | — | — | 1 | 5.19 |
| CHEMBL4549693 | — | — | 1 | 5.19 |
| CHEMBL4515648 | — | — | 1 | 5.18 |
| CHEMBL4577962 | — | — | 1 | 5.18 |
| CHEMBL4557275 | — | — | 1 | 5.18 |
| CHEMBL4593456 | — | — | 1 | 5.17 |
| CHEMBL4563502 | — | — | 1 | 5.17 |
| CHEMBL4577347 | — | — | 1 | 5.17 |
| CHEMBL4586300 | — | — | 1 | 5.16 |
| CHEMBL4566150 | — | — | 1 | 5.16 |
| CHEMBL4567848 | — | — | 1 | 5.15 |
| CHEMBL4582486 | — | — | 1 | 5.15 |
| CHEMBL4562804 | — | — | 1 | 5.15 |
| CHEMBL4532810 | — | — | 1 | 5.14 |
| CHEMBL4518562 | — | — | 1 | 5.14 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4591519 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4520667 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL4553929 | — | IC50 | = | 4610.0 | nM | 5.34 |
| CHEMBL4530326 | — | IC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL3764224 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL4537982 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4528556 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4579446 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL4518765 | — | IC50 | = | 5690.0 | nM | 5.25 |
| CHEMBL4562037 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4536809 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4536651 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4528926 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL3765324 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4536048 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4561696 | — | IC50 | = | 6520.0 | nM | 5.19 |
| CHEMBL4549693 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4515648 | — | IC50 | = | 6570.0 | nM | 5.18 |
| CHEMBL4577962 | — | IC50 | = | 6620.0 | nM | 5.18 |
| CHEMBL4557275 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4593456 | — | IC50 | = | 6760.0 | nM | 5.17 |
| CHEMBL4563502 | — | IC50 | = | 6810.0 | nM | 5.17 |
| CHEMBL4577347 | — | IC50 | = | 6720.0 | nM | 5.17 |
| CHEMBL4586300 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4566150 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4567848 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4562804 | — | IC50 | = | 7010.0 | nM | 5.15 |
| CHEMBL4582486 | — | IC50 | = | 7120.0 | nM | 5.15 |
| CHEMBL4532810 | — | IC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL4518562 | — | IC50 | = | 7200.0 | nM | 5.14 |
| CHEMBL4551784 | — | IC50 | = | 7530.0 | nM | 5.12 |
| CHEMBL4516080 | — | IC50 | = | 7660.0 | nM | 5.12 |
| CHEMBL4549864 | — | IC50 | = | 7660.0 | nM | 5.12 |
| CHEMBL4549148 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4542946 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL4543714 | — | IC50 | = | 8100.0 | nM | 5.09 |
| CHEMBL4546432 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4585094 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL4555286 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4538112 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL4525304 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4548354 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4575401 | — | IC50 | = | 9250.0 | nM | 5.03 |
| CHEMBL4556441 | — | IC50 | = | 9710.0 | nM | 5.01 |
| CHEMBL4515327 | — | IC50 | = | 12690.0 | nM | 4.90 |
| CHEMBL4519399 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL4552419 | — | IC50 | = | 13630.0 | nM | 4.87 |
| CHEMBL4569813 | — | IC50 | = | 16300.0 | nM | 4.79 |
| CHEMBL4553297 | — | IC50 | = | 25380.0 | nM | 4.60 |
| CHEMBL4586239 | — | IC50 | = | 27700.0 | nM | 4.56 |