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Assay Detail

CHEMBL4477002

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Functional
Cytotoxicity against human CCD-18Co cells assessed as reduction in cell viability incubated for 72 hrs by CCK8 assay
ChEMBL ↗
294
Total Activities
294
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type CCD-18Co
Confidence 1 — Organism
Curated By Autocuration

Target

CCD-18Co (CHEMBL4296405) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Bicyclic compound and use thereof for inhibiting suv39h2
(2018)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 294 5.39 6.48

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4526470 — — 1 6.48
CHEMBL4587622 — — 1 6.44
CHEMBL4520044 — — 1 6.42
CHEMBL4525814 — — 1 6.35
CHEMBL4526344 — — 1 6.33
CHEMBL4555239 — — 1 6.31
CHEMBL4559621 — — 1 6.28
CHEMBL4581193 — — 1 6.21
CHEMBL4555676 — — 1 6.16
CHEMBL4573508 — — 1 6.15
CHEMBL4541514 — — 1 6.14
CHEMBL4554238 — — 1 6.14
CHEMBL4583709 — — 1 6.12
CHEMBL4551239 — — 1 6.11
CHEMBL4561677 — — 1 6.11
CHEMBL4541772 — — 1 6.10
CHEMBL4526034 — — 1 6.09
CHEMBL4556415 — — 1 6.09
CHEMBL4533884 — — 1 6.08
CHEMBL4537646 — — 1 6.08
CHEMBL4586890 — — 1 6.08
CHEMBL4571602 — — 1 6.07
CHEMBL4570591 — — 1 6.06
CHEMBL4540007 — — 1 6.00
CHEMBL4547529 — — 1 5.96
CHEMBL4543316 — — 1 5.96
CHEMBL4565001 — — 1 5.96
CHEMBL4520199 — — 1 5.96
CHEMBL4483497 — — 1 5.96
CHEMBL4581530 — — 1 5.96

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4526470 — IC50 = 330.0 nM 6.48
CHEMBL4587622 — IC50 = 360.0 nM 6.44
CHEMBL4520044 — IC50 = 380.0 nM 6.42
CHEMBL4525814 — IC50 = 450.0 nM 6.35
CHEMBL4526344 — IC50 = 470.0 nM 6.33
CHEMBL4555239 — IC50 = 490.0 nM 6.31
CHEMBL4559621 — IC50 = 530.0 nM 6.28
CHEMBL4581193 — IC50 = 620.0 nM 6.21
CHEMBL4555676 — IC50 = 700.0 nM 6.16
CHEMBL4573508 — IC50 = 710.0 nM 6.15
CHEMBL4554238 — IC50 = 720.0 nM 6.14
CHEMBL4541514 — IC50 = 720.0 nM 6.14
CHEMBL4583709 — IC50 = 760.0 nM 6.12
CHEMBL4561677 — IC50 = 780.0 nM 6.11
CHEMBL4551239 — IC50 = 780.0 nM 6.11
CHEMBL4541772 — IC50 = 790.0 nM 6.10
CHEMBL4556415 — IC50 = 820.0 nM 6.09
CHEMBL4526034 — IC50 = 810.0 nM 6.09
CHEMBL4533884 — IC50 = 830.0 nM 6.08
CHEMBL4537646 — IC50 = 840.0 nM 6.08
CHEMBL4586890 — IC50 = 830.0 nM 6.08
CHEMBL4571602 — IC50 = 860.0 nM 6.07
CHEMBL4570591 — IC50 = 870.0 nM 6.06
CHEMBL4540007 — IC50 = 990.0 nM 6.00
CHEMBL4565001 — IC50 = 1100.0 nM 5.96
CHEMBL4543316 — IC50 = 1100.0 nM 5.96
CHEMBL4520199 — IC50 = 1100.0 nM 5.96
CHEMBL4483497 — IC50 = 1100.0 nM 5.96
CHEMBL4555204 — IC50 = 1100.0 nM 5.96
CHEMBL4547529 — IC50 = 1100.0 nM 5.96
CHEMBL4581530 — IC50 = 1100.0 nM 5.96
CHEMBL4550153 — IC50 = 1200.0 nM 5.92
CHEMBL4519801 — IC50 = 1300.0 nM 5.89
CHEMBL4579974 — IC50 = 1300.0 nM 5.89
CHEMBL4591418 — IC50 = 1300.0 nM 5.89
CHEMBL4574823 — IC50 = 1300.0 nM 5.89
CHEMBL4583879 — IC50 = 1300.0 nM 5.89
CHEMBL4536456 — IC50 = 1300.0 nM 5.89
CHEMBL4585143 — IC50 = 1300.0 nM 5.89
CHEMBL4571462 — IC50 = 1400.0 nM 5.85
CHEMBL4558804 — IC50 = 1400.0 nM 5.85
CHEMBL4579951 — IC50 = 1400.0 nM 5.85
CHEMBL4529303 — IC50 = 1400.0 nM 5.85
CHEMBL4513384 — IC50 = 1400.0 nM 5.85
CHEMBL4539367 — IC50 = 1400.0 nM 5.85
CHEMBL4585854 — IC50 = 1400.0 nM 5.85
CHEMBL4551838 — IC50 = 1400.0 nM 5.85
CHEMBL4557658 — IC50 = 1500.0 nM 5.82
CHEMBL4579876 — IC50 = 1500.0 nM 5.82
CHEMBL4541065 — IC50 = 1500.0 nM 5.82