Assay Detail
Binding
CHEMBL4477437
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PTP1B preincubated for 10 mins followed by protein addition using pNPP substrate
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of PTP1B and α-Glucosidase Inhibitory Serrulatanes from Eremophila spp. by Combined use of Dual High-Resolution PTP1B and α-Glucosidase Inhibition Profiling and HPLC-HRMS-SPE-NMR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 5 | - | - |
| IC50 | 5 | 5.29 | 5.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4567748 | — | — | 1 | 5.46 |
| CHEMBL426373 | — | — | 1 | 5.36 |
| CHEMBL4541029 | — | — | 1 | 5.20 |
| CHEMBL4528277 | — | — | 1 | 5.12 |
| CHEMBL4564293 | — | — | 1 | - |
| CHEMBL4544488 | — | — | 1 | - |
| CHEMBL4535279 | — | — | 1 | - |
| CHEMBL4593141 | — | — | 1 | - |
| CHEMBL4518229 | — | — | 1 | - |
| CHEMBL4566339 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4567748 | — | IC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL426373 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL4541029 | — | IC50 | = | 6270.0 | nM | 5.20 |
| CHEMBL4528277 | — | IC50 | = | 7670.0 | nM | 5.12 |
| CHEMBL4564293 | — | Inhibition | - | % | - | |
| CHEMBL4544488 | — | Inhibition | - | % | - | |
| CHEMBL4535279 | — | IC50 | = | 1260000.0 | nM | - |
| CHEMBL4593141 | — | Inhibition | - | % | - | |
| CHEMBL4518229 | — | Inhibition | - | % | - | |
| CHEMBL4566339 | — | Inhibition | - | % | - |