Assay Detail
Binding
CHEMBL4477438
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged human PTP1B expressed in Escherichia coli using pNPP substrate assessed as reduction in p-nitrophenol release
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of PTP1B and α-Glucosidase Inhibitory Serrulatanes from Eremophila spp. by Combined use of Dual High-Resolution PTP1B and α-Glucosidase Inhibition Profiling and HPLC-HRMS-SPE-NMR.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 5.36 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4554678 | — | — | 1 | 5.82 |
| CHEMBL403093 | OHIOENSIN A | — | 1 | 5.46 |
| CHEMBL4524583 | — | — | 1 | 5.46 |
| CHEMBL403094 | OHIOENSIN F | — | 1 | 5.46 |
| CHEMBL403411 | OHIOENSIN G | — | 1 | 5.46 |
| CHEMBL4561426 | — | — | 1 | 5.26 |
| CHEMBL4566713 | — | — | 1 | 5.23 |
| CHEMBL2086414 | RHODODENDRIC ACID A | — | 1 | 5.20 |
| CHEMBL523622 | — | — | 1 | 5.13 |
| CHEMBL1835376 | LOBOPHYTUMIN C | — | 1 | 5.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4554678 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL403093 | OHIOENSIN A | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4524583 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL403094 | OHIOENSIN F | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL403411 | OHIOENSIN G | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4561426 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4566713 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL2086414 | RHODODENDRIC ACID A | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL523622 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL1835376 | LOBOPHYTUMIN C | IC50 | = | 7800.0 | nM | 5.11 |