Assay Detail
Binding
CHEMBL4477671
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged Bcl-xL/5-carboxyfluorescein-Bak (unknown origin) after 1 hr by fluorescence polarization assay
14
Total Activities
14
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Anacardic Acids from Knema hookeriana as Modulators of Bcl-xL/Bak and Mcl-1/Bid Interactions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.75 | 6.70 |
| IC50 | 1 | 7.24 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | 1.0 | 1 | 7.24 |
| CHEMBL476921 | GINKGOLIC ACID 13:0 | — | 1 | 6.70 |
| CHEMBL4589399 | — | — | 1 | 6.52 |
| CHEMBL4451281 | — | — | 1 | 5.92 |
| CHEMBL556082 | MEIOGYNIN A | — | 1 | 5.58 |
| CHEMBL4589356 | — | — | 1 | 5.50 |
| CHEMBL470264 | — | — | 1 | 5.24 |
| CHEMBL4586537 | — | — | 1 | 4.79 |
| CHEMBL4590718 | — | — | 1 | - |
| CHEMBL448270 | — | — | 1 | - |
| CHEMBL1784991 | — | — | 1 | - |
| CHEMBL4551810 | — | — | 1 | - |
| CHEMBL4558011 | — | — | 1 | - |
| CHEMBL3590506 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL376408 | ABT 737 | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL476921 | GINKGOLIC ACID 13:0 | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL4589399 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL4451281 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL556082 | MEIOGYNIN A | Ki | = | 2600.0 | nM | 5.58 |
| CHEMBL4589356 | — | Ki | = | 3200.0 | nM | 5.50 |
| CHEMBL470264 | — | Ki | = | 5700.0 | nM | 5.24 |
| CHEMBL4586537 | — | Ki | = | 16300.0 | nM | 4.79 |
| CHEMBL4590718 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL448270 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL1784991 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4551810 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL4558011 | — | Ki | > | 23000.0 | nM | - |
| CHEMBL3590506 | — | Ki | > | 23000.0 | nM | - |