Compound Detail
CHEMBL476921
GINKGOLIC ACID 13:0 Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL476921 |
| Name | GINKGOLIC ACID 13:0 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VEPUCZUJLKAVNM-UHFFFAOYSA-N |
3
Targets
4
Activities
2
Assay Types
0
PK Parameters
18
Publications
0
Known Names
Molecular Properties
320.5
MW (Da)
5.94
ALogP
2
HBA
2
HBD
57.5
PSA (Ų)
0.44
QED
1
Ro5 Violations
13
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.79
Ki 2 meas. best 6.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bcl-xL/BAK CHEMBL3137283 | Ki | 6.7 | 6.7 | 200.0 | 1 |
| Induced myeloid leukemia cell differentiation protein Mcl-1/BH3-interacting domain death agonist CHEMBL3430886 | Ki | 6.7 | 6.7 | 200.0 | 1 |
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 CHEMBL5566 | IC50 | 4.79 | 4.79 | 16270.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Induced myeloid leukemia cell differentiation protein Mcl-1/BH3-interacting domain death agonist | Ki | = | 200.0 | nM | 6.7 | Inhibition of His-tagged Mcl-1/5-carboxyfluorescein-Bid (unknown origin) after 1... | 27008174 |
| Bcl-xL/BAK | Ki | = | 200.0 | nM | 6.7 | Inhibition of His-tagged Bcl-xL/5-carboxyfluorescein-Bak (unknown origin) after ... | 27008174 |
| 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 | IC50 | = | 16270.0 | nM | 4.79 | Inhibition of bovine brain PI-PLCgamma1 | 9677265 |
Literature References
Data from ChEMBL 36 via Core Engine