Assay Detail
Functional
CHEMBL4477893
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Antiproliferative activity against human LNCAP cells assessed as relative inhibition after 96 hrs by propidium iodide staining based fluorescence 2D monolayer assay
12
Total Activities
6
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | LNCaP |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design and synthesis of novel bicalutamide and enzalutamide derivatives as antiproliferative agents for the treatment of prostate cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.20 | 6.08 |
| IC70 | 6 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4572299 | — | — | 2 | 6.08 |
| CHEMBL4577418 | — | — | 2 | 5.79 |
| CHEMBL4555717 | — | — | 2 | 5.48 |
| CHEMBL409 | BICALUTAMIDE | 4.0 | 2 | 4.33 |
| CHEMBL63560 | (R)-BICALUTAMIDE | — | 2 | 4.33 |
| CHEMBL4513407 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4572299 | — | IC50 | = | 828.0 | nM | 6.08 |
| CHEMBL4577418 | — | IC50 | = | 1638.0 | nM | 5.79 |
| CHEMBL4555717 | — | IC50 | = | 3278.0 | nM | 5.48 |
| CHEMBL409 | BICALUTAMIDE | IC50 | = | 47266.0 | nM | 4.33 |
| CHEMBL63560 | (R)-BICALUTAMIDE | IC50 | = | 47002.0 | nM | 4.33 |
| CHEMBL4572299 | — | IC70 | = | 1.326 | uM | - |
| CHEMBL4555717 | — | IC70 | = | 3.547 | uM | - |
| CHEMBL409 | BICALUTAMIDE | IC70 | = | 60.92 | uM | - |
| CHEMBL4513407 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4513407 | — | IC70 | > | 100.0 | uM | - |
| CHEMBL63560 | (R)-BICALUTAMIDE | IC70 | = | 59.32 | uM | - |
| CHEMBL4577418 | — | IC70 | = | 7.887 | uM | - |