Assay Detail
Binding
CHEMBL4478052
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H](2R,7R)-10 from human NPY Y4 receptor expressed in CHO cells co-expressing Gqi5-mtAEQ after 90 mins in presence of L-15 medium by liquid scintillation counting
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
High Affinity Agonists of the Neuropeptide Y (NPY) Y4 Receptor Derived from the C-Terminal Pentapeptide of Human Pancreatic Polypeptide (hPP): Synthesis, Stereochemical Discrimination, and Radiolabeling.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.87 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4456247 | — | — | 1 | 8.70 |
| CHEMBL4522438 | — | — | 1 | 8.20 |
| CHEMBL4475071 | — | — | 1 | 7.77 |
| CHEMBL3040731 | — | — | 1 | 6.82 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4456247 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL4522438 | — | Ki | = | 6.3 | nM | 8.20 |
| CHEMBL4475071 | — | Ki | = | 17.0 | nM | 7.77 |
| CHEMBL3040731 | — | Ki | = | 150.0 | nM | 6.82 |