Assay Detail
Binding
CHEMBL4478189
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal FLAG-tagged recombinant mTOR (1362 to 2549 residues) (unknown origin) using Biotin-Ahx-Lys-Lys-Ala-Asn-Gln-Val-Phe-Leu-Gly-Phe-Thr-Tyr-Val-Ala-Pro-Ser-Val-Leu-Glu-Ser-Val-Lys-Glu-NH2 as substrate after 90 mins by AlphaScreen assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective, and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (ATM) Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.68 | 6.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4565988 | — | — | 1 | 6.74 |
| CHEMBL4527822 | — | — | 1 | 6.07 |
| CHEMBL4166405 | — | — | 1 | 5.83 |
| CHEMBL4218734 | — | — | 1 | 5.54 |
| CHEMBL4593348 | — | — | 1 | 5.46 |
| CHEMBL2143829 | — | — | 1 | 5.34 |
| CHEMBL222102 | KU-55933 | — | 1 | 5.25 |
| CHEMBL2140173 | — | — | 1 | 5.18 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4565988 | — | IC50 | = | 181.0 | nM | 6.74 |
| CHEMBL4527822 | — | IC50 | = | 846.0 | nM | 6.07 |
| CHEMBL4166405 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL4218734 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL4593348 | — | IC50 | = | 3450.0 | nM | 5.46 |
| CHEMBL2143829 | — | IC50 | = | 4590.0 | nM | 5.34 |
| CHEMBL222102 | KU-55933 | IC50 | = | 5580.0 | nM | 5.25 |
| CHEMBL2140173 | — | IC50 | = | 6550.0 | nM | 5.18 |