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Assay Detail

CHEMBL4479404

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Functional
Antiproliferative activity against human LNCAP cells after 7 days by MTT assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type LNCaP
Confidence 1 — Organism
Curated By Autocuration

Target

LNCaP (CHEMBL612518)
Type CELL-LINE
Organism Homo sapiens

Publication

Identification of Novel Steroidal Androgen Receptor Degrading Agents Inspired by Galeterone 3β-Imidazole Carbamate.
Purushottamachar P, Kwegyir-Afful AK, Martin MS, Ramamurthy VP, Ramalingam S, Njar VC.
ACS Med Chem Lett (2016) 7 : 708 -713
PubMed 27437082 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 5.31 5.79

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4591875 1 5.79
CHEMBL4541575 1 5.61
CHEMBL2105738 GALETERONE 3.0 1 5.41
CHEMBL4552506 1 5.41
CHEMBL4581336 1 5.37
CHEMBL1082407 ENZALUTAMIDE 4.0 1 5.31
CHEMBL4593419 1 5.29
CHEMBL4539707 1 5.18
CHEMBL4528465 1 5.16
CHEMBL4521939 1 5.06
CHEMBL4588643 1 5.05
CHEMBL4532487 1 5.02
CHEMBL254328 ABIRATERONE 3.0 1 -
CHEMBL4520316 1 -
CHEMBL4564188 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4591875 IC50 = 1640.0 nM 5.79
CHEMBL4541575 IC50 = 2450.0 nM 5.61
CHEMBL2105738 GALETERONE IC50 = 3930.0 nM 5.41
CHEMBL4552506 IC50 = 3890.0 nM 5.41
CHEMBL4581336 IC50 = 4260.0 nM 5.37
CHEMBL1082407 ENZALUTAMIDE IC50 = 4850.0 nM 5.31
CHEMBL4593419 IC50 = 5120.0 nM 5.29
CHEMBL4539707 IC50 = 6610.0 nM 5.18
CHEMBL4528465 IC50 = 6910.0 nM 5.16
CHEMBL4521939 IC50 = 8710.0 nM 5.06
CHEMBL4588643 IC50 = 8910.0 nM 5.05
CHEMBL4532487 IC50 = 9570.0 nM 5.02
CHEMBL254328 ABIRATERONE IC50 - -
CHEMBL4520316 IC50 - -
CHEMBL4564188 IC50 - -