Assay Detail
Binding
CHEMBL4479555
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PRMT5 (unknown origin)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Protein arginine N-methyltransferase 5 (CHEMBL1795116) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
New small molecule inhibitors of histone methyl transferase DOT1L with a nitrile as a non-traditional replacement for heavy halogen atoms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.16 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL418052 | S-ADENOSYLHOMOCYSTEINE | — | 1 | 6.70 |
| CHEMBL4588797 | — | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL418052 | S-ADENOSYLHOMOCYSTEINE | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4588797 | — | IC50 | = | 2400.0 | nM | 5.62 |