Assay Detail
Functional
CHEMBL4480048
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Antiproliferative activity against human K562/ADR cells after 72 hrs by CCK8 assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | K562/Adr |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of the multidrug resistance-reversing activity of pyridine acid esters of podophyllotoxin in human leukemia cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 6.79 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | 4.0 | 1 | 7.60 |
| CHEMBL4583480 | — | — | 1 | 7.34 |
| CHEMBL2262705 | 4-O-PODOPHYLLOTOXINYL-ISONICOTINATE | — | 1 | 7.32 |
| CHEMBL4532302 | — | — | 1 | 7.28 |
| CHEMBL4564011 | — | — | 1 | 7.24 |
| CHEMBL4520609 | — | — | 1 | 7.24 |
| CHEMBL4593889 | — | — | 1 | 6.91 |
| CHEMBL2262706 | 4-O-PODOPHYLLOTOXINYL-NICOTINATE | — | 1 | 6.86 |
| CHEMBL4562262 | — | — | 1 | 6.84 |
| CHEMBL4518242 | — | — | 1 | 6.80 |
| CHEMBL4589693 | — | — | 1 | 6.46 |
| CHEMBL44657 | ETOPOSIDE | 4.0 | 1 | 5.69 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 4.73 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL61 | PODOFILOX | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4583480 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL2262705 | 4-O-PODOPHYLLOTOXINYL-ISONICOTINATE | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4532302 | — | IC50 | = | 52.0 | nM | 7.28 |
| CHEMBL4564011 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4520609 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4593889 | — | IC50 | = | 123.0 | nM | 6.91 |
| CHEMBL2262706 | 4-O-PODOPHYLLOTOXINYL-NICOTINATE | IC50 | = | 137.0 | nM | 6.86 |
| CHEMBL4562262 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL4518242 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4589693 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL44657 | ETOPOSIDE | IC50 | = | 2025.0 | nM | 5.69 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 18779.0 | nM | 4.73 |