Assay Detail
Binding
CHEMBL4480315
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ATG4B (unknown origin) expressed in HEK293T cells coexpressing HTRA4 and Actin-LC3B-dNGLuc after 24 hrs by luciferase release assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 5.78 | 7.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4581663 | — | — | 1 | 7.82 |
| CHEMBL4546760 | — | — | 1 | 7.22 |
| CHEMBL4520267 | — | — | 1 | 7.14 |
| CHEMBL4520585 | — | — | 1 | 6.89 |
| CHEMBL4553669 | — | — | 1 | 6.64 |
| CHEMBL4567870 | — | — | 1 | 6.28 |
| CHEMBL4574173 | — | — | 1 | 6.04 |
| CHEMBL4579064 | — | — | 1 | 6.02 |
| CHEMBL4567655 | — | — | 1 | 5.92 |
| CHEMBL4588146 | — | — | 1 | 5.90 |
| CHEMBL4572200 | — | — | 1 | 5.83 |
| CHEMBL4539211 | — | — | 1 | 5.75 |
| CHEMBL4535723 | — | — | 1 | 5.75 |
| CHEMBL4590201 | — | — | 1 | 5.59 |
| CHEMBL4578571 | — | — | 1 | 5.52 |
| CHEMBL4569375 | — | — | 1 | 5.39 |
| CHEMBL4562540 | — | — | 1 | 5.35 |
| CHEMBL2402203 | — | — | 1 | 5.29 |
| CHEMBL4570064 | — | — | 1 | 5.25 |
| CHEMBL4525169 | — | — | 1 | 4.91 |
| CHEMBL4540188 | — | — | 1 | 4.87 |
| CHEMBL4527514 | — | — | 1 | 4.46 |
| CHEMBL4515617 | — | — | 1 | 4.42 |
| CHEMBL4566110 | — | — | 1 | 4.42 |
| CHEMBL4520698 | — | — | 1 | - |
| CHEMBL4529816 | — | — | 1 | - |
| CHEMBL4563886 | — | — | 1 | - |
| CHEMBL4564704 | — | — | 1 | - |
| CHEMBL4204523 | — | — | 1 | - |
| CHEMBL344174 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4581663 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4546760 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4520267 | — | IC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4520585 | — | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4553669 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4567870 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4574173 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4579064 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL4567655 | — | IC50 | = | 1190.0 | nM | 5.92 |
| CHEMBL4588146 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4572200 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL4539211 | — | IC50 | = | 1780.0 | nM | 5.75 |
| CHEMBL4535723 | — | IC50 | = | 1760.0 | nM | 5.75 |
| CHEMBL4590201 | — | IC50 | = | 2570.0 | nM | 5.59 |
| CHEMBL4578571 | — | IC50 | = | 2990.0 | nM | 5.52 |
| CHEMBL4569375 | — | IC50 | = | 4060.0 | nM | 5.39 |
| CHEMBL4562540 | — | IC50 | = | 4470.0 | nM | 5.35 |
| CHEMBL2402203 | — | IC50 | = | 5090.0 | nM | 5.29 |
| CHEMBL4570064 | — | IC50 | = | 5680.0 | nM | 5.25 |
| CHEMBL4525169 | — | IC50 | = | 12300.0 | nM | 4.91 |
| CHEMBL4540188 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL4527514 | — | IC50 | = | 34300.0 | nM | 4.46 |
| CHEMBL4515617 | — | IC50 | = | 38100.0 | nM | 4.42 |
| CHEMBL4566110 | — | IC50 | = | 37600.0 | nM | 4.42 |
| CHEMBL4554009 | — | IC50 | - | — | - | |
| CHEMBL4566679 | — | IC50 | - | — | - | |
| CHEMBL4556657 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4568708 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4594129 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4527093 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4555270 | — | IC50 | - | — | - | |
| CHEMBL4218185 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4549686 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL344174 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4204523 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4564704 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4563886 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4529816 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4520698 | — | IC50 | > | 100000.0 | nM | - |