Assay Detail
Binding
CHEMBL4480326
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of caspase3 (unknown origin) using Ac-DMQD-AMC as substrate preincubated for 20 mins followed by substrate addition by fluorescence plate reader analysis
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Fluoromethylketone-Based Peptidomimetics as Covalent ATG4B (Autophagin-1) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.24 | 4.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2402203 | — | — | 1 | 4.36 |
| CHEMBL4520267 | — | — | 1 | 4.12 |
| CHEMBL4590201 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2402203 | — | IC50 | = | 43500.0 | nM | 4.36 |
| CHEMBL4520267 | — | IC50 | = | 75100.0 | nM | 4.12 |
| CHEMBL4590201 | — | IC50 | > | 100000.0 | nM | - |