Assay Detail
Binding
CHEMBL4480546
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Inhibition of wild type Influenza A virus (A/chicken/Hubei/327/2004(H5N1)) M2 expressed in yeast cells after 46 to 48 hrs
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Influenza A virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Matrix protein 2 (CHEMBL2052) ↗| Type | SINGLE PROTEIN |
| Organism | Influenza A virus (A/Udorn/307/1972(H3N2)) |
Publication
Design and synthesis of heteroaromatic-based benzenesulfonamide derivatives as potent inhibitors of H5N1 influenza A virus.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 35 | 5.26 | 6.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL660 | AMANTADINE | 4.0 | 1 | 6.18 |
| CHEMBL4586535 | — | — | 1 | 5.97 |
| CHEMBL4557613 | — | — | 1 | 5.85 |
| CHEMBL4527406 | — | — | 1 | 5.80 |
| CHEMBL4517321 | — | — | 1 | 5.77 |
| CHEMBL4528685 | — | — | 1 | 5.70 |
| CHEMBL4518980 | — | — | 1 | 5.66 |
| CHEMBL4544193 | — | — | 1 | 5.62 |
| CHEMBL4557215 | — | — | 1 | 5.51 |
| CHEMBL4534199 | — | — | 1 | 5.46 |
| CHEMBL4592186 | — | — | 1 | 5.33 |
| CHEMBL4579348 | — | — | 1 | 5.27 |
| CHEMBL4588491 | — | — | 1 | 5.21 |
| CHEMBL4586595 | — | — | 1 | 4.89 |
| CHEMBL4527371 | — | — | 1 | 4.82 |
| CHEMBL4567651 | — | — | 1 | 4.64 |
| CHEMBL4574356 | — | — | 1 | 4.62 |
| CHEMBL4538304 | — | — | 1 | 4.56 |
| CHEMBL4581693 | — | — | 1 | 4.34 |
| CHEMBL4590782 | — | — | 1 | 4.09 |
| CHEMBL1200340 | OSELTAMIVIR PHOSPHATE | 4.0 | 1 | - |
| CHEMBL4540325 | — | — | 1 | - |
| CHEMBL4564406 | — | — | 1 | - |
| CHEMBL4519600 | — | — | 1 | - |
| CHEMBL4591526 | — | — | 1 | - |
| CHEMBL4546727 | — | — | 1 | - |
| CHEMBL4514902 | — | — | 1 | - |
| CHEMBL4539682 | — | — | 1 | - |
| CHEMBL4551543 | — | — | 1 | - |
| CHEMBL4518870 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL660 | AMANTADINE | EC50 | = | 660.0 | nM | 6.18 |
| CHEMBL4586535 | — | EC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4557613 | — | EC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4527406 | — | EC50 | = | 1580.0 | nM | 5.80 |
| CHEMBL4517321 | — | EC50 | = | 1710.0 | nM | 5.77 |
| CHEMBL4528685 | — | EC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL4518980 | — | EC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL4544193 | — | EC50 | = | 2380.0 | nM | 5.62 |
| CHEMBL4557215 | — | EC50 | = | 3070.0 | nM | 5.51 |
| CHEMBL4534199 | — | EC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL4592186 | — | EC50 | = | 4650.0 | nM | 5.33 |
| CHEMBL4579348 | — | EC50 | = | 5330.0 | nM | 5.27 |
| CHEMBL4588491 | — | EC50 | = | 6220.0 | nM | 5.21 |
| CHEMBL4586595 | — | EC50 | = | 12740.0 | nM | 4.89 |
| CHEMBL4527371 | — | EC50 | = | 15250.0 | nM | 4.82 |
| CHEMBL4567651 | — | EC50 | = | 22680.0 | nM | 4.64 |
| CHEMBL4574356 | — | EC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4538304 | — | EC50 | = | 27790.0 | nM | 4.56 |
| CHEMBL4581693 | — | EC50 | = | 45670.0 | nM | 4.34 |
| CHEMBL4590782 | — | EC50 | = | 81480.0 | nM | 4.09 |
| CHEMBL4543323 | — | EC50 | - | — | - | |
| CHEMBL4515951 | — | EC50 | - | — | - | |
| CHEMBL4537555 | — | EC50 | - | — | - | |
| CHEMBL4559127 | — | EC50 | - | — | - | |
| CHEMBL4543160 | — | EC50 | - | — | - | |
| CHEMBL4518870 | — | EC50 | - | — | - | |
| CHEMBL4551543 | — | EC50 | - | — | - | |
| CHEMBL4539682 | — | EC50 | - | — | - | |
| CHEMBL4514902 | — | EC50 | - | — | - | |
| CHEMBL4546727 | — | EC50 | - | — | - | |
| CHEMBL4591526 | — | EC50 | - | — | - | |
| CHEMBL4519600 | — | EC50 | - | — | - | |
| CHEMBL4564406 | — | EC50 | - | — | - | |
| CHEMBL4540325 | — | EC50 | - | — | - | |
| CHEMBL1200340 | OSELTAMIVIR PHOSPHATE | EC50 | - | — | - |