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Assay Detail

CHEMBL4480587

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of bovine milk xanthine oxidase using xanthine as substrate preincubated for 5 mins followed by substrate addition by UV-visible spectrophotometry
34
Total Activities
34
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Bos taurus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Xanthine dehydrogenase/oxidase (CHEMBL3649)
Type SINGLE PROTEIN
Organism Bos taurus

Publication

Benzoflavone derivatives as potent antihyperuricemic agents.
Singh JV, Mal G, Kaur G, Gupta MK, Singh A, Nepali K, Singh H, Sharma S, S Bedi PM.
Medchemcomm (2019) 10 : 128 -147
PubMed 30931089 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 34 5.23 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1164729 FEBUXOSTAT 4.0 1 7.52
CHEMBL359819 1 6.21
CHEMBL179925 1 5.71
CHEMBL361608 1 5.31
CHEMBL4285956 1 5.28
CHEMBL4084903 1 5.16
CHEMBL4278699 1 5.12
CHEMBL1467 ALLOPURINOL 4.0 1 5.06
CHEMBL4078823 1 5.05
CHEMBL4284553 1 5.05
CHEMBL4292058 1 4.91
CHEMBL599338 1 4.83
CHEMBL4099439 1 4.78
CHEMBL4277659 1 4.77
CHEMBL4285597 1 4.73
CHEMBL2420082 1 4.72
CHEMBL4096846 1 4.71
CHEMBL283196 ALPHA-NAPHTHOFLAVONE 1 -
CHEMBL4292384 1 -
CHEMBL4284177 1 -
CHEMBL4081273 1 -
CHEMBL4586894 1 -
CHEMBL2420093 1 -
CHEMBL4281483 1 -
CHEMBL26260 BETA-NAPHTHOFLAVONE 1 -
CHEMBL4278030 1 -
CHEMBL4097793 1 -
CHEMBL436080 1 -
CHEMBL4288983 1 -
CHEMBL368236 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1164729 FEBUXOSTAT IC50 = 30.0 nM 7.52
CHEMBL359819 IC50 = 620.0 nM 6.21
CHEMBL179925 IC50 = 1950.0 nM 5.71
CHEMBL361608 IC50 = 4940.0 nM 5.31
CHEMBL4285956 IC50 = 5210.0 nM 5.28
CHEMBL4084903 IC50 = 6950.0 nM 5.16
CHEMBL4278699 IC50 = 7670.0 nM 5.12
CHEMBL1467 ALLOPURINOL IC50 = 8690.0 nM 5.06
CHEMBL4078823 IC50 = 8930.0 nM 5.05
CHEMBL4284553 IC50 = 8900.0 nM 5.05
CHEMBL4292058 IC50 = 12440.0 nM 4.91
CHEMBL599338 IC50 = 14670.0 nM 4.83
CHEMBL4099439 IC50 = 16800.0 nM 4.78
CHEMBL4277659 IC50 = 17070.0 nM 4.77
CHEMBL4285597 IC50 = 18580.0 nM 4.73
CHEMBL2420082 IC50 = 18900.0 nM 4.72
CHEMBL4096846 IC50 = 19400.0 nM 4.71
CHEMBL4292778 IC50 > 20000.0 nM -
CHEMBL4086963 IC50 > 20000.0 nM -
CHEMBL177059 IC50 > 20000.0 nM -
CHEMBL4069506 IC50 > 20000.0 nM -
CHEMBL368236 IC50 > 20000.0 nM -
CHEMBL4288983 IC50 > 20000.0 nM -
CHEMBL436080 IC50 > 20000.0 nM -
CHEMBL4097793 IC50 > 20000.0 nM -
CHEMBL4278030 IC50 > 20000.0 nM -
CHEMBL26260 BETA-NAPHTHOFLAVONE IC50 > 20000.0 nM -
CHEMBL4281483 IC50 > 20000.0 nM -
CHEMBL2420093 IC50 > 20000.0 nM -
CHEMBL4586894 IC50 > 20000.0 nM -
CHEMBL4081273 IC50 > 20000.0 nM -
CHEMBL4284177 IC50 > 20000.0 nM -
CHEMBL4292384 IC50 > 20000.0 nM -
CHEMBL283196 ALPHA-NAPHTHOFLAVONE IC50 > 20000.0 nM -