Assay Detail
Binding
CHEMBL4480636
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]DPCPX from adenosine A1 receptor in rat brain membranes in presence of GTP by radioligand competition assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Brain |
| Subcellular | Membranes |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Methoxy substituted 2-benzylidene-1-indanone derivatives as A1 and/or A2A AR antagonists for the potential treatment of neurological conditions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 7.52 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | — | 1 | 9.40 |
| CHEMBL4572336 | — | — | 1 | 7.22 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | — | 1 | 7.00 |
| CHEMBL4547939 | — | — | 1 | 6.47 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL183 | 1,3-DIPROPYL-8-CYCLOPENTYLXANTHINE [DPCPX] | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL4572336 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL68738 | N6-CYCLOPENTYLADENOSINE | Ki | = | 99.0 | nM | 7.00 |
| CHEMBL4547939 | — | Ki | = | 339.0 | nM | 6.47 |