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Assay Detail

CHEMBL4480790

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against African green monkey Vero cells after 72 hrs by propidium iodide/fluorescein diacetate staining based flow cytometry
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Chlorocebus sabaeus
Cell Type Vero
Confidence 1 — Organism
Curated By Autocuration

Target

Vero (CHEMBL391)
Type CELL-LINE
Organism Chlorocebus sabaeus

Publication

Design, synthesis and molecular docking studies of novel N-arylsulfonyl-benzimidazoles with anti Trypanosoma cruzi activity.
Miana GE, Ribone SR, Vera DMA, Sánchez-Moreno M, Mazzieri MR, Quevedo MA.
Eur J Med Chem (2019) 165 : 1 -10
PubMed 30641409 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 4.42 4.87

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL110 BENZNIDAZOLE 4.0 1 4.87
CHEMBL4519223 1 4.22
CHEMBL4519623 1 4.16
CHEMBL4534114 1 -
CHEMBL4535715 1 -
CHEMBL4580128 1 -
CHEMBL4583963 1 -
CHEMBL1439907 1 -
CHEMBL4570536 1 -
CHEMBL1493289 1 -
CHEMBL1890994 1 -
CHEMBL1519988 1 -
CHEMBL4551736 1 -
CHEMBL1729716 1 -
CHEMBL3112679 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL110 BENZNIDAZOLE IC50 = 13600.0 nM 4.87
CHEMBL4519223 IC50 = 59800.0 nM 4.22
CHEMBL4519623 IC50 = 68500.0 nM 4.16
CHEMBL4534114 IC50 = 205300.0 nM -
CHEMBL4535715 IC50 = 459800.0 nM -
CHEMBL4580128 IC50 = 346700.0 nM -
CHEMBL4583963 IC50 = 647700.0 nM -
CHEMBL1439907 IC50 = 120100.0 nM -
CHEMBL4570536 IC50 = 1188000.0 nM -
CHEMBL1493289 IC50 = 122500.0 nM -
CHEMBL1890994 IC50 = 986900.0 nM -
CHEMBL1519988 IC50 = 107600.0 nM -
CHEMBL4551736 IC50 = 656400.0 nM -
CHEMBL1729716 IC50 = 468100.0 nM -
CHEMBL3112679 IC50 = 1765600.0 nM -