Assay Detail
ADMET
CHEMBL4480805
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Cytotoxicity against BHK21 cells after 72 hrs by MTT assay
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mesocricetus auratus |
| Cell Type | BHK-21 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and anticancer evaluation of new lipophilic 1,2,4 and 1,3,4-oxadiazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 4.63 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL178 | DAUNORUBICIN | 4.0 | 1 | 7.05 |
| CHEMBL4543692 | — | — | 1 | 6.05 |
| CHEMBL4564492 | — | — | 1 | 5.66 |
| CHEMBL4529515 | — | — | 1 | 5.21 |
| CHEMBL4572453 | — | — | 1 | 5.07 |
| CHEMBL4547329 | — | — | 1 | 4.94 |
| CHEMBL4570866 | — | — | 1 | 4.90 |
| CHEMBL4579706 | — | — | 1 | 4.87 |
| CHEMBL4585976 | — | — | 1 | 4.79 |
| CHEMBL4562698 | — | — | 1 | 4.72 |
| CHEMBL4575358 | — | — | 1 | 4.70 |
| CHEMBL4549285 | — | — | 1 | 4.68 |
| CHEMBL4520590 | — | — | 1 | 4.66 |
| CHEMBL4576092 | — | — | 1 | 4.66 |
| CHEMBL4539509 | — | — | 1 | 4.65 |
| CHEMBL4538414 | — | — | 1 | 4.64 |
| CHEMBL4554581 | — | — | 1 | 4.64 |
| CHEMBL4537958 | — | — | 1 | 4.63 |
| CHEMBL4566444 | — | — | 1 | 4.62 |
| CHEMBL4585342 | — | — | 1 | 4.57 |
| CHEMBL4541668 | — | — | 1 | 4.54 |
| CHEMBL4583999 | — | — | 1 | 4.50 |
| CHEMBL4565669 | — | — | 1 | 4.49 |
| CHEMBL4560572 | — | — | 1 | 4.46 |
| CHEMBL4513417 | — | — | 1 | 4.32 |
| CHEMBL4586733 | — | — | 1 | 4.25 |
| CHEMBL4584654 | — | — | 1 | 4.23 |
| CHEMBL4537353 | — | — | 1 | 4.22 |
| CHEMBL4567283 | — | — | 1 | 4.20 |
| CHEMBL4589665 | — | — | 1 | 4.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL178 | DAUNORUBICIN | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4543692 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4564492 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4529515 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL4572453 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4547329 | — | IC50 | = | 11600.0 | nM | 4.94 |
| CHEMBL4570866 | — | IC50 | = | 12700.0 | nM | 4.90 |
| CHEMBL4579706 | — | IC50 | = | 13400.0 | nM | 4.87 |
| CHEMBL4585976 | — | IC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL4562698 | — | IC50 | = | 18900.0 | nM | 4.72 |
| CHEMBL4575358 | — | IC50 | = | 19800.0 | nM | 4.70 |
| CHEMBL4549285 | — | IC50 | = | 21100.0 | nM | 4.68 |
| CHEMBL4520590 | — | IC50 | = | 22100.0 | nM | 4.66 |
| CHEMBL4576092 | — | IC50 | = | 21900.0 | nM | 4.66 |
| CHEMBL4539509 | — | IC50 | = | 22600.0 | nM | 4.65 |
| CHEMBL4538414 | — | IC50 | = | 22900.0 | nM | 4.64 |
| CHEMBL4554581 | — | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL4537958 | — | IC50 | = | 23300.0 | nM | 4.63 |
| CHEMBL4566444 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL4585342 | — | IC50 | = | 27200.0 | nM | 4.57 |
| CHEMBL4541668 | — | IC50 | = | 28600.0 | nM | 4.54 |
| CHEMBL4583999 | — | IC50 | = | 31800.0 | nM | 4.50 |
| CHEMBL4565669 | — | IC50 | = | 32500.0 | nM | 4.49 |
| CHEMBL4560572 | — | IC50 | = | 34400.0 | nM | 4.46 |
| CHEMBL4513417 | — | IC50 | = | 48300.0 | nM | 4.32 |
| CHEMBL4586733 | — | IC50 | = | 56300.0 | nM | 4.25 |
| CHEMBL4584654 | — | IC50 | = | 58600.0 | nM | 4.23 |
| CHEMBL4537353 | — | IC50 | = | 60300.0 | nM | 4.22 |
| CHEMBL4567283 | — | IC50 | = | 62700.0 | nM | 4.20 |
| CHEMBL4589665 | — | IC50 | = | 64600.0 | nM | 4.19 |
| CHEMBL4545028 | — | IC50 | = | 66300.0 | nM | 4.18 |
| CHEMBL4554732 | — | IC50 | = | 69500.0 | nM | 4.16 |
| CHEMBL4534874 | — | IC50 | = | 71400.0 | nM | 4.15 |
| CHEMBL4543578 | — | IC50 | = | 74000.0 | nM | 4.13 |
| CHEMBL4546443 | — | IC50 | = | 76100.0 | nM | 4.12 |
| CHEMBL4589031 | — | IC50 | = | 83400.0 | nM | 4.08 |
| CHEMBL4569063 | — | IC50 | = | 87300.0 | nM | 4.06 |
| CHEMBL4539974 | — | IC50 | = | 94600.0 | nM | 4.02 |
| CHEMBL4555208 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4537437 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4513563 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4590572 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4544920 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4513746 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4525278 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4578884 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4577045 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4560517 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4555595 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4527907 | — | IC50 | > | 100000.0 | nM | - |