Assay Detail
Functional
CHEMBL4480964
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Cytotoxicity against human HCT15 cells after 72 hrs by MTT assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-15 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and synthesis of sulfur-containing 6-substituted 5,8-dimethoxy-1,4-naphthoquinone oxime derivatives as new and potential anti-MDR cancer agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.60 | 6.42 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4592400 | — | — | 1 | 6.42 |
| CHEMBL4522076 | — | — | 1 | 6.34 |
| CHEMBL4587009 | — | — | 1 | 6.30 |
| CHEMBL4580459 | — | — | 1 | 6.28 |
| CHEMBL4521851 | — | — | 1 | 6.27 |
| CHEMBL4585496 | — | — | 1 | 6.09 |
| CHEMBL4587116 | — | — | 1 | 6.09 |
| CHEMBL9470 | SHIKONIN | — | 1 | 6.07 |
| CHEMBL4532225 | — | — | 1 | 6.05 |
| CHEMBL4552164 | — | — | 1 | 6.04 |
| CHEMBL4564124 | — | — | 1 | 6.01 |
| CHEMBL4565324 | — | — | 1 | 5.98 |
| CHEMBL4483767 | — | — | 1 | 5.97 |
| CHEMBL4522322 | — | — | 1 | 5.91 |
| CHEMBL4553974 | — | — | 1 | 5.86 |
| CHEMBL4573022 | — | — | 1 | 5.66 |
| CHEMBL4537554 | — | — | 1 | 5.63 |
| CHEMBL4561935 | — | — | 1 | 5.62 |
| CHEMBL4562143 | — | — | 1 | 5.56 |
| CHEMBL4591861 | — | — | 1 | 5.54 |
| CHEMBL4590949 | — | — | 1 | 5.42 |
| CHEMBL4590861 | — | — | 1 | 5.41 |
| CHEMBL4589953 | — | — | 1 | 5.32 |
| CHEMBL4526822 | — | — | 1 | 5.28 |
| CHEMBL4527771 | — | — | 1 | 5.27 |
| CHEMBL4577864 | — | — | 1 | 5.20 |
| CHEMBL4540173 | — | — | 1 | 5.13 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 5.12 |
| CHEMBL4538567 | — | — | 1 | 5.11 |
| CHEMBL4563431 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4592400 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL4522076 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL4587009 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL4580459 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4521851 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4585496 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4587116 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL9470 | SHIKONIN | IC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4532225 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4552164 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4564124 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4565324 | — | IC50 | = | 1040.0 | nM | 5.98 |
| CHEMBL4483767 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4522322 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL4553974 | — | IC50 | = | 1390.0 | nM | 5.86 |
| CHEMBL4573022 | — | IC50 | = | 2210.0 | nM | 5.66 |
| CHEMBL4537554 | — | IC50 | = | 2320.0 | nM | 5.63 |
| CHEMBL4561935 | — | IC50 | = | 2420.0 | nM | 5.62 |
| CHEMBL4562143 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL4591861 | — | IC50 | = | 2920.0 | nM | 5.54 |
| CHEMBL4590949 | — | IC50 | = | 3820.0 | nM | 5.42 |
| CHEMBL4590861 | — | IC50 | = | 3890.0 | nM | 5.41 |
| CHEMBL4589953 | — | IC50 | = | 4750.0 | nM | 5.32 |
| CHEMBL4526822 | — | IC50 | = | 5230.0 | nM | 5.28 |
| CHEMBL4527771 | — | IC50 | = | 5420.0 | nM | 5.27 |
| CHEMBL4577864 | — | IC50 | = | 6340.0 | nM | 5.20 |
| CHEMBL4540173 | — | IC50 | = | 7330.0 | nM | 5.13 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 7530.0 | nM | 5.12 |
| CHEMBL4538567 | — | IC50 | = | 7730.0 | nM | 5.11 |
| CHEMBL4563431 | — | IC50 | = | 7980.0 | nM | 5.10 |
| CHEMBL4483353 | — | IC50 | = | 10280.0 | nM | 4.99 |
| CHEMBL4529765 | — | IC50 | = | 12520.0 | nM | 4.90 |
| CHEMBL4572166 | — | IC50 | = | 12970.0 | nM | 4.89 |
| CHEMBL4552860 | — | IC50 | = | 22520.0 | nM | 4.65 |
| CHEMBL4543337 | — | IC50 | = | 35180.0 | nM | 4.45 |