Assay Detail
Binding
CHEMBL4481506
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Binding affinity to C-terminal AVI-tagged GAK (unknown origin) (12 to 347 residues) expressed in Escherichia coli after 1.5 hrs by TR-FRET assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SGC-GAK-1: A Chemical Probe for Cyclin G Associated Kinase (GAK).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.62 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4443342 | — | — | 1 | 8.51 |
| CHEMBL4531690 | — | — | 1 | 8.42 |
| CHEMBL4535001 | — | — | 1 | 7.31 |
| CHEMBL3823499 | — | — | 1 | 6.66 |
| CHEMBL4462395 | — | — | 1 | 5.60 |
| CHEMBL4514780 | — | — | 1 | 5.09 |
| CHEMBL4518437 | — | — | 1 | 4.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4443342 | — | Ki | = | 3.1 | nM | 8.51 |
| CHEMBL4531690 | — | Ki | = | 3.8 | nM | 8.42 |
| CHEMBL4535001 | — | Ki | = | 49.0 | nM | 7.31 |
| CHEMBL3823499 | — | Ki | = | 220.0 | nM | 6.66 |
| CHEMBL4462395 | — | Ki | = | 2500.0 | nM | 5.60 |
| CHEMBL4514780 | — | Ki | = | 8200.0 | nM | 5.09 |
| CHEMBL4518437 | — | Ki | = | 19000.0 | nM | 4.72 |