Assay Detail
Binding
CHEMBL4481538
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR L858R/T790M double mutant (unknown origin) by HTRF assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting the MKK7-JNK (Mitogen-Activated Protein Kinase Kinase 7-c-Jun N-Terminal Kinase) Pathway with Covalent Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.13 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4094959 | — | — | 1 | 8.52 |
| CHEMBL4534592 | — | — | 1 | 7.55 |
| CHEMBL1873475 | IBRUTINIB | 4.0 | 1 | 7.40 |
| CHEMBL4584630 | — | — | 1 | 6.98 |
| CHEMBL4588202 | — | — | 1 | 6.17 |
| CHEMBL4071151 | — | — | 1 | 6.16 |
| CHEMBL4581088 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4094959 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4534592 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL1873475 | IBRUTINIB | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4584630 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4588202 | — | IC50 | = | 677.0 | nM | 6.17 |
| CHEMBL4071151 | — | IC50 | = | 693.0 | nM | 6.16 |
| CHEMBL4581088 | — | IC50 | > | 1000.0 | nM | - |