Assay Detail
Binding
CHEMBL4481771
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Displacement of [3H]CCPA from adenosine A1 receptor in rat brain cortical membranes
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel multi-target directed ligands based on annelated xanthine scaffold with aromatic substituents acting on adenosine receptor and monoamine oxidase B. Synthesis, in vitro and in silico studies.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 25 | 5.75 | 6.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL431770 | ISTRADEFYLLINE | 4.0 | 1 | 6.64 |
| CHEMBL241618 | — | — | 1 | 6.37 |
| CHEMBL4531455 | — | — | 1 | 6.31 |
| CHEMBL4560961 | — | — | 1 | 6.03 |
| CHEMBL4570974 | — | — | 1 | 6.03 |
| CHEMBL4537668 | — | — | 1 | 6.01 |
| CHEMBL4558859 | — | — | 1 | 5.85 |
| CHEMBL4521517 | — | — | 1 | 5.81 |
| CHEMBL4540760 | — | — | 1 | 5.75 |
| CHEMBL4563999 | — | — | 1 | 5.72 |
| CHEMBL4535750 | — | — | 1 | 5.63 |
| CHEMBL4574105 | — | — | 1 | 5.58 |
| CHEMBL4592888 | — | — | 1 | 5.52 |
| CHEMBL4569201 | — | — | 1 | 5.38 |
| CHEMBL4533073 | — | — | 1 | 5.36 |
| CHEMBL4517925 | — | — | 1 | 5.31 |
| CHEMBL113 | CAFFEINE | 4.0 | 1 | 4.39 |
| CHEMBL4574192 | — | — | 1 | - |
| CHEMBL4580206 | — | — | 1 | - |
| CHEMBL4554986 | — | — | 1 | - |
| CHEMBL4576786 | — | — | 1 | - |
| CHEMBL4566592 | — | — | 1 | - |
| CHEMBL4579395 | — | — | 1 | - |
| CHEMBL4565406 | — | — | 1 | - |
| CHEMBL4546819 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL431770 | ISTRADEFYLLINE | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL241618 | — | Ki | = | 432.0 | nM | 6.37 |
| CHEMBL4531455 | — | Ki | = | 486.0 | nM | 6.31 |
| CHEMBL4560961 | — | Ki | = | 931.0 | nM | 6.03 |
| CHEMBL4570974 | — | Ki | = | 927.0 | nM | 6.03 |
| CHEMBL4537668 | — | Ki | = | 965.0 | nM | 6.01 |
| CHEMBL4558859 | — | Ki | = | 1410.0 | nM | 5.85 |
| CHEMBL4521517 | — | Ki | = | 1550.0 | nM | 5.81 |
| CHEMBL4540760 | — | Ki | = | 1780.0 | nM | 5.75 |
| CHEMBL4563999 | — | Ki | = | 1910.0 | nM | 5.72 |
| CHEMBL4535750 | — | Ki | = | 2320.0 | nM | 5.63 |
| CHEMBL4574105 | — | Ki | = | 2650.0 | nM | 5.58 |
| CHEMBL4592888 | — | Ki | = | 3020.0 | nM | 5.52 |
| CHEMBL4569201 | — | Ki | = | 4130.0 | nM | 5.38 |
| CHEMBL4533073 | — | Ki | = | 4360.0 | nM | 5.36 |
| CHEMBL4517925 | — | Ki | = | 4900.0 | nM | 5.31 |
| CHEMBL113 | CAFFEINE | Ki | = | 41000.0 | nM | 4.39 |
| CHEMBL4574192 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4580206 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4554986 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4576786 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4566592 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4579395 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4565406 | — | Ki | > | 1000.0 | nM | - |
| CHEMBL4546819 | — | Ki | > | 1000.0 | nM | - |