Assay Detail
Functional
CHEMBL4482015
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against rat T cells cultured with Concanavalin A for 24 hrs assessed inhibition of IL-2-stimulated cell proliferation after 72 hrs by MTS assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | T-cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based design and synthesis of pyrimidine-4,6-diamine derivatives as Janus kinase 3 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.72 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 8.70 |
| CHEMBL3601722 | — | — | 1 | 7.92 |
| CHEMBL4573218 | — | — | 1 | 7.82 |
| CHEMBL4574614 | — | — | 1 | 7.39 |
| CHEMBL4546009 | — | — | 1 | 7.30 |
| CHEMBL4518786 | — | — | 1 | 7.19 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221959 | TOFACITINIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL3601722 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4573218 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4574614 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL4546009 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4518786 | — | IC50 | = | 64.0 | nM | 7.19 |