Assay Detail
Binding
CHEMBL4482188
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Inhibition of OAT3 (unknown origin) expressed in HEK293 cells assessed as reduction in 6-CF uptake measured after 5 mins by fluorescence assay
15
Total Activities
8
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Dihydrophenanthrenes from Juncus effusus as Inhibitors of OAT1 and OAT3.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.49 | 5.96 |
| Inhibition | 7 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4519013 | — | — | 2 | 5.96 |
| CHEMBL4562825 | — | — | 2 | 5.96 |
| CHEMBL4584575 | — | — | 2 | 5.89 |
| CHEMBL4527448 | — | — | 2 | 5.64 |
| CHEMBL4582456 | — | — | 2 | 5.55 |
| CHEMBL38650 | — | — | 2 | 5.19 |
| CHEMBL4525573 | — | — | 2 | 5.08 |
| CHEMBL205119 | EFFUSOL | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4519013 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4562825 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4584575 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4527448 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4582456 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL38650 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4525573 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL205119 | EFFUSOL | IC50 | = | 22700.0 | nM | 4.64 |
| CHEMBL4584575 | — | Inhibition | - | % | - | |
| CHEMBL4519013 | — | Inhibition | - | % | - | |
| CHEMBL4582456 | — | Inhibition | - | % | - | |
| CHEMBL38650 | — | Inhibition | - | % | - | |
| CHEMBL4562825 | — | Inhibition | - | % | - | |
| CHEMBL4525573 | — | Inhibition | - | % | - | |
| CHEMBL4527448 | — | Inhibition | - | % | - |