Assay Detail
Binding
CHEMBL4482465
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged recombinant human fascin 1 expressed in Escherichia coli BL21/DE3 assessed as inhibition of actin fiber growth pre-incubated for 30 mins before polymerized actin addition and followed by Alexa fluro 488 phalloidin addition and measured after 1 hr under dark condition
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Methods for inhibiting fascin
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 5.67 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3559101 | — | — | 1 | 6.30 |
| CHEMBL1188627 | — | — | 1 | 6.30 |
| CHEMBL3235902 | — | — | 1 | 6.27 |
| CHEMBL4539339 | — | — | 1 | 6.19 |
| CHEMBL4526942 | — | — | 1 | 6.17 |
| CHEMBL4440859 | — | — | 1 | 6.13 |
| CHEMBL1540929 | — | — | 1 | 6.09 |
| CHEMBL4524644 | — | — | 1 | 6.05 |
| CHEMBL4549117 | — | — | 1 | 5.92 |
| CHEMBL3235888 | — | — | 1 | 5.83 |
| CHEMBL4554206 | — | — | 1 | 5.70 |
| CHEMBL1740740 | — | — | 1 | 5.70 |
| CHEMBL4569970 | — | — | 1 | 5.70 |
| CHEMBL4553279 | — | — | 1 | 5.70 |
| CHEMBL4556783 | — | — | 1 | 5.70 |
| CHEMBL4580744 | — | — | 1 | 5.68 |
| CHEMBL4582975 | — | — | 1 | 5.64 |
| CHEMBL3235887 | — | — | 1 | 5.58 |
| CHEMBL590438 | — | — | 1 | 5.57 |
| CHEMBL4546807 | — | — | 1 | 5.47 |
| CHEMBL4521764 | — | — | 1 | 5.43 |
| CHEMBL4589339 | — | — | 1 | 5.40 |
| CHEMBL4536804 | — | — | 1 | 5.40 |
| CHEMBL571729 | — | — | 1 | 5.40 |
| CHEMBL4557461 | — | — | 1 | 5.37 |
| CHEMBL4521304 | — | — | 1 | 5.37 |
| CHEMBL4548547 | — | — | 1 | 5.34 |
| CHEMBL4559590 | — | — | 1 | 5.33 |
| CHEMBL1740060 | — | — | 1 | 5.30 |
| CHEMBL4549154 | — | — | 1 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3559101 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL1188627 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL3235902 | — | IC50 | = | 539.0 | nM | 6.27 |
| CHEMBL4539339 | — | IC50 | = | 652.0 | nM | 6.19 |
| CHEMBL4526942 | — | IC50 | = | 683.0 | nM | 6.17 |
| CHEMBL4440859 | — | IC50 | = | 734.0 | nM | 6.13 |
| CHEMBL1540929 | — | IC50 | = | 807.0 | nM | 6.09 |
| CHEMBL4524644 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL4549117 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL3235888 | — | IC50 | = | 1470.0 | nM | 5.83 |
| CHEMBL4554206 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL1740740 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4569970 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4553279 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4556783 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL4580744 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4582975 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL3235887 | — | IC50 | = | 2620.0 | nM | 5.58 |
| CHEMBL590438 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4546807 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL4521764 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4589339 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4536804 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL571729 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4557461 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4521304 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL4548547 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4559590 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1740060 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4549154 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL4587111 | — | IC50 | = | 13000.0 | nM | 4.89 |