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Assay Detail

CHEMBL4482726

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of terbium-labeled SNAP-tagged human SPR in presence of sulfasalazine-labeled SNAP-tagged EGFP by homogenous TR-FRET assay
ChEMBL ↗
834
Total Activities
834
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Sepiapterin reductase (CHEMBL3988583) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Sepiapterin reductase inhibitors
(2018)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 834 8.24 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4547958 — — 1 9.00
CHEMBL4542770 — — 1 9.00
CHEMBL4554183 — — 1 9.00
CHEMBL4560694 — — 1 9.00
CHEMBL4550973 — — 1 9.00
CHEMBL4525234 — — 1 9.00
CHEMBL4554154 — — 1 9.00
CHEMBL4590566 — — 1 9.00
CHEMBL4536114 — — 1 9.00
CHEMBL4528266 — — 1 9.00
CHEMBL4567692 — — 1 9.00
CHEMBL4583036 — — 1 9.00
CHEMBL4562897 — — 1 9.00
CHEMBL4586926 — — 1 9.00
CHEMBL4530729 — — 1 9.00
CHEMBL4565940 — — 1 9.00
CHEMBL4543843 — — 1 9.00
CHEMBL4568013 — — 1 9.00
CHEMBL4576651 — — 1 9.00
CHEMBL4570174 — — 1 9.00
CHEMBL4549931 — — 1 9.00
CHEMBL4522277 — — 1 9.00
CHEMBL4562479 — — 1 9.00
CHEMBL4550453 — — 1 9.00
CHEMBL4591533 — — 1 9.00
CHEMBL4526479 — — 1 9.00
CHEMBL4541433 — — 1 9.00
CHEMBL4554662 — — 1 9.00
CHEMBL4518409 — — 1 9.00
CHEMBL4539575 — — 1 9.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4519582 — IC50 = 1.0 nM 9.00
CHEMBL4567232 — IC50 = 1.0 nM 9.00
CHEMBL4527039 — IC50 = 1.0 nM 9.00
CHEMBL4580860 — IC50 = 1.0 nM 9.00
CHEMBL4544111 — IC50 = 1.0 nM 9.00
CHEMBL4559708 — IC50 = 1.0 nM 9.00
CHEMBL4565400 — IC50 = 1.0 nM 9.00
CHEMBL4520726 — IC50 = 1.0 nM 9.00
CHEMBL4568767 — IC50 = 1.0 nM 9.00
CHEMBL4536070 — IC50 = 1.0 nM 9.00
CHEMBL4593801 — IC50 = 1.0 nM 9.00
CHEMBL4574342 — IC50 = 1.0 nM 9.00
CHEMBL4525880 — IC50 = 1.0 nM 9.00
CHEMBL4563610 — IC50 = 1.0 nM 9.00
CHEMBL4563028 — IC50 = 1.0 nM 9.00
CHEMBL4520342 — IC50 = 1.0 nM 9.00
CHEMBL4565427 — IC50 = 1.0 nM 9.00
CHEMBL4556382 — IC50 = 1.0 nM 9.00
CHEMBL4590828 — IC50 = 1.0 nM 9.00
CHEMBL4573411 — IC50 = 1.0 nM 9.00
CHEMBL4559335 — IC50 = 1.0 nM 9.00
CHEMBL4530795 — IC50 = 1.0 nM 9.00
CHEMBL4541887 — IC50 = 1.0 nM 9.00
CHEMBL4548349 — IC50 = 1.0 nM 9.00
CHEMBL4567346 — IC50 = 1.0 nM 9.00
CHEMBL4576695 — IC50 = 1.0 nM 9.00
CHEMBL4528785 — IC50 = 1.0 nM 9.00
CHEMBL4548342 — IC50 = 1.0 nM 9.00
CHEMBL4526438 — IC50 = 1.0 nM 9.00
CHEMBL4574375 — IC50 = 1.0 nM 9.00
CHEMBL4588585 — IC50 = 1.0 nM 9.00
CHEMBL4579266 — IC50 = 1.0 nM 9.00
CHEMBL4546282 — IC50 = 1.0 nM 9.00
CHEMBL4580426 — IC50 = 1.0 nM 9.00
CHEMBL4483582 — IC50 = 1.0 nM 9.00
CHEMBL4576820 — IC50 = 1.0 nM 9.00
CHEMBL4558607 — IC50 = 1.0 nM 9.00
CHEMBL4581306 — IC50 = 1.0 nM 9.00
CHEMBL4570950 — IC50 = 1.0 nM 9.00
CHEMBL4554750 — IC50 = 1.0 nM 9.00
CHEMBL4535900 — IC50 = 1.0 nM 9.00
CHEMBL4544487 — IC50 = 1.0 nM 9.00
CHEMBL4528123 — IC50 = 1.0 nM 9.00
CHEMBL4513597 — IC50 = 1.0 nM 9.00
CHEMBL4548880 — IC50 = 1.0 nM 9.00
CHEMBL4586547 — IC50 = 1.0 nM 9.00
CHEMBL4554274 — IC50 = 1.0 nM 9.00
CHEMBL4563700 — IC50 = 1.0 nM 9.00
CHEMBL4549697 — IC50 = 1.0 nM 9.00
CHEMBL4571723 — IC50 = 1.0 nM 9.00