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Assay Detail

CHEMBL4482728

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Binding
Inhibition of SPR in human SK-N-BE(2) cells assessed as reduction in BH4 levels incubated for 6 to 48 hrs by LCMS analysis
ChEMBL ↗
640
Total Activities
640
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Sepiapterin reductase (CHEMBL3988583) ↗
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Sepiapterin reductase inhibitors
(2018)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 640 6.30 8.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4538572 — — 1 8.00
CHEMBL4559529 — — 1 7.96
CHEMBL4513512 — — 1 7.96
CHEMBL4547921 — — 1 7.92
CHEMBL4513856 — — 1 7.92
CHEMBL4548446 — — 1 7.85
CHEMBL4582841 — — 1 7.82
CHEMBL4571342 — — 1 7.80
CHEMBL4532978 — — 1 7.80
CHEMBL4526206 — — 1 7.75
CHEMBL4591104 — — 1 7.72
CHEMBL4577016 — — 1 7.72
CHEMBL4550680 — — 1 7.72
CHEMBL4522114 — — 1 7.72
CHEMBL4590728 — — 1 7.70
CHEMBL4528738 — — 1 7.68
CHEMBL4570696 — — 1 7.66
CHEMBL4526750 — — 1 7.64
CHEMBL4582061 — — 1 7.62
CHEMBL4517548 — — 1 7.60
CHEMBL4576731 — — 1 7.55
CHEMBL4559223 — — 1 7.55
CHEMBL4560694 — — 1 7.55
CHEMBL4526479 — — 1 7.55
CHEMBL4572311 — — 1 7.54
CHEMBL4575533 — — 1 7.54
CHEMBL4517606 — — 1 7.52
CHEMBL4586985 — — 1 7.52
CHEMBL4568728 — — 1 7.50
CHEMBL4539053 — — 1 7.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4538572 — IC50 = 10.0 nM 8.00
CHEMBL4513512 — IC50 = 11.0 nM 7.96
CHEMBL4559529 — IC50 = 11.0 nM 7.96
CHEMBL4547921 — IC50 = 12.0 nM 7.92
CHEMBL4513856 — IC50 = 12.0 nM 7.92
CHEMBL4548446 — IC50 = 14.0 nM 7.85
CHEMBL4582841 — IC50 = 15.0 nM 7.82
CHEMBL4532978 — IC50 = 16.0 nM 7.80
CHEMBL4571342 — IC50 = 16.0 nM 7.80
CHEMBL4526206 — IC50 = 18.0 nM 7.75
CHEMBL4522114 — IC50 = 19.0 nM 7.72
CHEMBL4550680 — IC50 = 19.0 nM 7.72
CHEMBL4577016 — IC50 = 19.0 nM 7.72
CHEMBL4591104 — IC50 = 19.0 nM 7.72
CHEMBL4590728 — IC50 = 20.0 nM 7.70
CHEMBL4528738 — IC50 = 21.0 nM 7.68
CHEMBL4570696 — IC50 = 22.0 nM 7.66
CHEMBL4526750 — IC50 = 23.0 nM 7.64
CHEMBL4582061 — IC50 = 24.0 nM 7.62
CHEMBL4517548 — IC50 = 25.0 nM 7.60
CHEMBL4559223 — IC50 = 28.0 nM 7.55
CHEMBL4526479 — IC50 = 28.0 nM 7.55
CHEMBL4576731 — IC50 = 28.0 nM 7.55
CHEMBL4560694 — IC50 = 28.0 nM 7.55
CHEMBL4575533 — IC50 = 29.0 nM 7.54
CHEMBL4572311 — IC50 = 29.0 nM 7.54
CHEMBL4586985 — IC50 = 30.0 nM 7.52
CHEMBL4517606 — IC50 = 30.0 nM 7.52
CHEMBL4539053 — IC50 = 32.0 nM 7.50
CHEMBL4568728 — IC50 = 32.0 nM 7.50
CHEMBL4563409 — IC50 = 33.0 nM 7.48
CHEMBL4517598 — IC50 = 35.0 nM 7.46
CHEMBL4573571 — IC50 = 35.0 nM 7.46
CHEMBL4549991 — IC50 = 36.0 nM 7.44
CHEMBL4516829 — IC50 = 37.0 nM 7.43
CHEMBL4588980 — IC50 = 37.0 nM 7.43
CHEMBL4576469 — IC50 = 38.0 nM 7.42
CHEMBL4541978 — IC50 = 38.0 nM 7.42
CHEMBL4540783 — IC50 = 40.0 nM 7.40
CHEMBL4525340 — IC50 = 41.0 nM 7.39
CHEMBL4590443 — IC50 = 41.0 nM 7.39
CHEMBL4559779 — IC50 = 41.0 nM 7.39
CHEMBL4574510 — IC50 = 43.0 nM 7.37
CHEMBL4556161 — IC50 = 44.0 nM 7.36
CHEMBL4546220 — IC50 = 44.0 nM 7.36
CHEMBL4539420 — IC50 = 44.0 nM 7.36
CHEMBL4550453 — IC50 = 44.0 nM 7.36
CHEMBL4565571 — IC50 = 45.0 nM 7.35
CHEMBL4576651 — IC50 = 46.0 nM 7.34
CHEMBL4565399 — IC50 = 47.0 nM 7.33