Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4513083

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of VERO-E6 cells after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
ChEMBL ↗
318
Total Activities
147
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Chlorocebus sabaeus
Cell Type Vero C1008
Confidence 1 — Organism
Curated By Autocuration

Target

SARS-CoV-2 (CHEMBL4303835) ↗
Type ORGANISM
Organism Severe acute respiratory syndrome coronavirus 2

Publication

Cytopathic SARS-Cov2 screening on VERO-E6 cells in a large repurposing effort
Andrea Zaliani, Laura Vangeel, Jeanette Reinshagen, Daniela Iaconis, Maria Kuzikov, Oliver Keminer, Markus Wolf, Bernhard Ellinger, Francesca Esposito, Angela Corona, Enzo Tramontano, Candida Manelfi, Katja Herzog, Dirk Jochmans, Steven De Jonghe, Winston Chiu, Thibault Francken, Joost Schepers, Caroline Collard, Kayvan Abbasi, Carsten Claussen , Vincenzo Summa, Andrea R. Beccari, Johan Neyts, Philip Gribbon and Pieter Leyssen
(2020)
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 318 5.35 7.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL19980 BREFELDIN A — 2 7.70
CHEMBL34259 METHOTREXATE 4.0 2 7.30
CHEMBL1201746 PRALATREXATE 4.0 2 7.22
CHEMBL423192 ANISOMYCIN — 2 7.05
CHEMBL2134545 — — 2 6.96
CHEMBL286494 HYPERICIN 3.0 2 6.60
CHEMBL64925 MG-132 — 4 6.50
CHEMBL1186894 AMRUBICIN 3.0 2 6.48
CHEMBL119 TRIMETREXATE 4.0 2 6.48
CHEMBL376180 AMINOPTERIN 2.0 2 6.46
CHEMBL374632 — — 2 6.44
CHEMBL3407547 FIRSOCOSTAT 2.0 2 6.42
CHEMBL2135651 — — 2 6.42
CHEMBL3913746 — — 2 6.40
CHEMBL1234354 PF-04691502 2.0 4 6.26
CHEMBL1057 FLUORESCEIN 4.0 2 6.17
CHEMBL1565817 — — 2 6.10
CHEMBL245839 — — 2 6.10
CHEMBL78150 TYRPHOSTIN A9 — 4 6.08
CHEMBL3989914 GLESATINIB 2.0 2 5.98
CHEMBL3349001 AVN-944 2.0 2 5.94
CHEMBL123292 CYCLOHEXIMIDE 2.0 2 5.94
CHEMBL365141 — — 2 5.94
CHEMBL270515 DELANZOMIB 2.0 2 5.89
CHEMBL4303620 — — 2 5.88
CHEMBL154745 — — 2 5.68
CHEMBL1922094 APITOLISIB 2.0 2 5.64
CHEMBL264373 METOPRINE -1.0 2 5.63
CHEMBL3989870 BERZOSERTIB 2.0 4 5.57
CHEMBL5314365 MONENSIN SODIUM 4.0 2 5.50

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL19980 BREFELDIN A IC50 = 20.0 nM 7.70
CHEMBL19980 BREFELDIN A IC50 = 20.0 nM 7.70
CHEMBL34259 METHOTREXATE IC50 = 50.0 nM 7.30
CHEMBL34259 METHOTREXATE IC50 = 50.0 nM 7.30
CHEMBL1201746 PRALATREXATE IC50 = 60.0 nM 7.22
CHEMBL1201746 PRALATREXATE IC50 = 60.0 nM 7.22
CHEMBL423192 ANISOMYCIN IC50 = 90.0 nM 7.05
CHEMBL423192 ANISOMYCIN IC50 = 90.0 nM 7.05
CHEMBL2134545 — IC50 = 110.0 nM 6.96
CHEMBL2134545 — IC50 = 110.0 nM 6.96
CHEMBL286494 HYPERICIN IC50 = 250.0 nM 6.60
CHEMBL286494 HYPERICIN IC50 = 250.0 nM 6.60
CHEMBL64925 MG-132 IC50 = 320.0 nM 6.50
CHEMBL64925 MG-132 IC50 = 320.0 nM 6.50
CHEMBL1186894 AMRUBICIN IC50 = 330.0 nM 6.48
CHEMBL119 TRIMETREXATE IC50 = 330.0 nM 6.48
CHEMBL119 TRIMETREXATE IC50 = 330.0 nM 6.48
CHEMBL1186894 AMRUBICIN IC50 = 330.0 nM 6.48
CHEMBL376180 AMINOPTERIN IC50 = 350.0 nM 6.46
CHEMBL376180 AMINOPTERIN IC50 = 350.0 nM 6.46
CHEMBL374632 — IC50 = 360.0 nM 6.44
CHEMBL374632 — IC50 = 360.0 nM 6.44
CHEMBL3407547 FIRSOCOSTAT IC50 = 380.0 nM 6.42
CHEMBL2135651 — IC50 = 380.0 nM 6.42
CHEMBL2135651 — IC50 = 380.0 nM 6.42
CHEMBL3407547 FIRSOCOSTAT IC50 = 380.0 nM 6.42
CHEMBL3913746 — IC50 = 400.0 nM 6.40
CHEMBL3913746 — IC50 = 400.0 nM 6.40
CHEMBL1234354 PF-04691502 IC50 = 550.0 nM 6.26
CHEMBL1234354 PF-04691502 IC50 = 550.0 nM 6.26
CHEMBL1057 FLUORESCEIN IC50 = 670.0 nM 6.17
CHEMBL1057 FLUORESCEIN IC50 = 670.0 nM 6.17
CHEMBL1565817 — IC50 = 790.0 nM 6.10
CHEMBL245839 — IC50 = 800.0 nM 6.10
CHEMBL1565817 — IC50 = 790.0 nM 6.10
CHEMBL245839 — IC50 = 800.0 nM 6.10
CHEMBL1234354 PF-04691502 IC50 = 800.0 nM 6.10
CHEMBL1234354 PF-04691502 IC50 = 800.0 nM 6.10
CHEMBL78150 TYRPHOSTIN A9 IC50 = 830.0 nM 6.08
CHEMBL78150 TYRPHOSTIN A9 IC50 = 830.0 nM 6.08
CHEMBL64925 MG-132 IC50 = 990.0 nM 6.00
CHEMBL64925 MG-132 IC50 = 990.0 nM 6.00
CHEMBL3989914 GLESATINIB IC50 = 1040.0 nM 5.98
CHEMBL3989914 GLESATINIB IC50 = 1040.0 nM 5.98
CHEMBL123292 CYCLOHEXIMIDE IC50 = 1160.0 nM 5.94
CHEMBL123292 CYCLOHEXIMIDE IC50 = 1160.0 nM 5.94
CHEMBL3349001 AVN-944 IC50 = 1140.0 nM 5.94
CHEMBL365141 — IC50 = 1150.0 nM 5.94
CHEMBL3349001 AVN-944 IC50 = 1140.0 nM 5.94
CHEMBL365141 — IC50 = 1150.0 nM 5.94