Assay Detail
Binding
CHEMBL4602758
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Antagonist activity at 5-HT6 receptor (unknown origin)
7
Total Activities
7
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Pharmaceutical and medicinal significance of sulfur (S<sup>VI</sup>)-Containing motifs for drug discovery: A critical review.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 5 | 7.39 | 8.27 |
| IC50 | 2 | 5.13 | 5.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4649783 | — | — | 1 | 8.27 |
| CHEMBL4635924 | — | — | 1 | 8.08 |
| CHEMBL4638578 | — | — | 1 | 7.77 |
| CHEMBL362628 | — | — | 1 | 6.51 |
| CHEMBL4632617 | — | — | 1 | 6.30 |
| CHEMBL4644799 | — | — | 1 | 5.41 |
| CHEMBL4643549 | — | — | 1 | 4.85 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4649783 | — | Ki | = | 5.4 | nM | 8.27 |
| CHEMBL4635924 | — | Ki | = | 8.4 | nM | 8.08 |
| CHEMBL4638578 | — | Ki | = | 16.9 | nM | 7.77 |
| CHEMBL362628 | — | Ki | = | 312.0 | nM | 6.51 |
| CHEMBL4632617 | — | Ki | = | 500.0 | nM | 6.30 |
| CHEMBL4644799 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4643549 | — | IC50 | = | 14000.0 | nM | 4.85 |