Assay Detail

CHEMBL4602775

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional

Antiviral activity against HCV genotype 1a

ChEMBL ↗

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Target

Hepatitis C virus (CHEMBL379) ↗

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Primary target Hepatitis C virus

CHEMBL379

Anchored from Assay target.

Protein identity Hepatitis C virus

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Hepacivirus hominis
Confidence	1 — Organism
Curated By	Autocuration

Target

Hepatitis C virus (CHEMBL379) ↗

Type	ORGANISM
Organism	Hepacivirus hominis

Publication

A review on HCV inhibitors: Significance of non-structural polyproteins.

Ganta NM, Gedda G, Rathnakar B, Satyanarayana M, Yamajala B, Ahsan MJ, Jadav SS, Balaraju T.
Eur J Med Chem (2019) 164 : 576 -601
PubMed 30639895 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	9.48	10.77

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL4643303	—	—	1	10.77
CHEMBL1241348	FALDAPREVIR	3.0	1	8.19

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL4643303	—	EC50	=	0.017	nM	10.77
CHEMBL1241348	FALDAPREVIR	EC50	=	6.5	nM	8.19