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Compound Detail

CHEMBL4643303

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COC(=O)N[C@H](C(=O)N1C[C@H](C)C[C@@H]1c1nc2sc(-c3ccc(-c4ccc(-c5c[nH]c([C@@H]6[C@H](C)CCN6C(=O)[C@H](NC(=O)OC)C(C)C)n5)cc4)cc3)cc2[nH]1)C(C)C

Basic Information

ChEMBL ID CHEMBL4643303
Phase Preclinical
Structure Type MOL
InChI Key NCKZSPQITDNJLX-WOWARFGQSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

823.0
MW (Da)
7.93
ALogP
9
HBA
4
HBD
174.6
PSA (Ų)
0.10
QED
2
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C44H54N8O6S
MW 823.03
Aromatic Rings 5
Heavy Atoms 59
NP-Likeness -0.42

Activity Summary

EC50 2 meas. best 10.77

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Hepatitis C virus
CHEMBL379
EC50 10.77 10.77 0.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Hepatitis C virus EC50 = 0.017 nM 10.77 Antiviral activity against HCV genotype 1a 30639895

Literature References

PubMed DOI Target Context # Activities
30639895 10.1016/j.ejmech.2018.12.045 Hepatitis C virus 2

Data from ChEMBL 36 via Core Engine