Assay Detail
Binding
CHEMBL4602784
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Inhibition of human p38alpha
22
Total Activities
18
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.42 | 6.82 |
| Ki | 4 | 6.73 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4129018 | MW-150 | 2.0 | 2 | 7.00 |
| CHEMBL4648060 | — | — | 2 | 6.96 |
| CHEMBL4639028 | — | — | 1 | 6.82 |
| CHEMBL4647072 | — | — | 1 | 6.80 |
| CHEMBL4646628 | — | — | 2 | 6.75 |
| CHEMBL4639995 | — | — | 1 | 6.70 |
| CHEMBL4635988 | — | — | 1 | 6.60 |
| CHEMBL4643246 | — | — | 1 | 6.54 |
| CHEMBL4642101 | — | — | 1 | 6.52 |
| CHEMBL4648747 | — | — | 1 | 6.41 |
| CHEMBL4645737 | — | — | 1 | 6.31 |
| CHEMBL4635980 | — | — | 1 | 6.24 |
| CHEMBL4639555 | — | — | 1 | 6.22 |
| CHEMBL4632881 | — | — | 2 | 6.22 |
| CHEMBL4642456 | — | — | 1 | 6.20 |
| CHEMBL4640881 | — | — | 1 | 6.15 |
| CHEMBL4643993 | — | — | 1 | 6.04 |
| CHEMBL4643060 | — | — | 1 | 5.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4129018 | MW-150 | Ki | = | 100.0 | nM | 7.00 |
| CHEMBL4648060 | — | Ki | = | 110.0 | nM | 6.96 |
| CHEMBL4639028 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4647072 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4646628 | — | Ki | = | 180.0 | nM | 6.75 |
| CHEMBL4646628 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4639995 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4648060 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL4129018 | MW-150 | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4635988 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4643246 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4642101 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4648747 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL4645737 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4635980 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL4639555 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4632881 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4632881 | — | Ki | = | 620.0 | nM | 6.21 |
| CHEMBL4642456 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4640881 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL4643993 | — | IC50 | = | 920.0 | nM | 6.04 |
| CHEMBL4643060 | — | IC50 | = | 1590.0 | nM | 5.80 |