Assay Detail
Binding
CHEMBL4602786
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Inhibition of human CK1delta
20
Total Activities
19
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A Selective and Brain Penetrant p38αMAPK Inhibitor Candidate for Neurologic and Neuropsychiatric Disorders That Attenuates Neuroinflammation and Cognitive Dysfunction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 5.94 | 7.30 |
| Ki | 1 | 7.40 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4632881 | — | — | 2 | 7.40 |
| CHEMBL4639028 | — | — | 1 | 7.30 |
| CHEMBL4639555 | — | — | 1 | 6.96 |
| CHEMBL4648747 | — | — | 1 | 6.60 |
| CHEMBL4635980 | — | — | 1 | 6.50 |
| CHEMBL4642101 | — | — | 1 | 6.47 |
| CHEMBL4645737 | — | — | 1 | 6.15 |
| CHEMBL4647072 | — | — | 1 | 5.70 |
| CHEMBL4129018 | MW-150 | 2.0 | 1 | 5.58 |
| CHEMBL4639995 | — | — | 1 | 5.50 |
| CHEMBL4643993 | — | — | 1 | 5.28 |
| CHEMBL4643246 | — | — | 1 | 5.23 |
| CHEMBL4648060 | — | — | 1 | 5.18 |
| CHEMBL4635988 | — | — | 1 | 5.04 |
| CHEMBL4643060 | — | — | 1 | 5.00 |
| CHEMBL4642456 | — | — | 1 | - |
| CHEMBL4640881 | — | — | 1 | - |
| CHEMBL4646628 | — | — | 1 | - |
| CHEMBL10 | SB-203580 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4632881 | — | Ki | = | 40.0 | nM | 7.40 |
| CHEMBL4639028 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL4639555 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4632881 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL4648747 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4635980 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL4642101 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4645737 | — | IC50 | = | 710.0 | nM | 6.15 |
| CHEMBL4647072 | — | IC50 | = | 2020.0 | nM | 5.70 |
| CHEMBL4129018 | MW-150 | IC50 | = | 2610.0 | nM | 5.58 |
| CHEMBL4639995 | — | IC50 | = | 3190.0 | nM | 5.50 |
| CHEMBL4643993 | — | IC50 | = | 5210.0 | nM | 5.28 |
| CHEMBL4643246 | — | IC50 | = | 5830.0 | nM | 5.23 |
| CHEMBL4648060 | — | IC50 | = | 6650.0 | nM | 5.18 |
| CHEMBL4635988 | — | IC50 | = | 9130.0 | nM | 5.04 |
| CHEMBL4643060 | — | IC50 | = | 10020.0 | nM | 5.00 |
| CHEMBL4642456 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4640881 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4646628 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL10 | SB-203580 | IC50 | < | 1000.0 | nM | - |