Assay Detail
Binding
CHEMBL4603684
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Inhibition of human CETP
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis, biological evaluation and SAR studies of ursolic acid 3β-ester derivatives as novel CETP inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.71 | 7.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1800807 | ANACETRAPIB | 3.0 | 1 | 7.44 |
| CHEMBL4634660 | — | — | 1 | 5.62 |
| CHEMBL509269 | — | — | 1 | 5.50 |
| CHEMBL4647341 | — | — | 1 | 5.48 |
| CHEMBL4646529 | — | — | 1 | 5.26 |
| CHEMBL508934 | — | — | 1 | 4.96 |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1800807 | ANACETRAPIB | IC50 | = | 36.0 | nM | 7.44 |
| CHEMBL4634660 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL509269 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4647341 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL4646529 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL508934 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL169 | URSOLIC ACID | IC50 | > | 50000.0 | nM | - |