Assay Detail
Binding
CHEMBL4604290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PDE1A (unknown origin)
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (CHEMBL3421) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and biological evaluation of Vinpocetine derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 4.56 | 5.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4633023 | — | — | 1 | 5.43 |
| CHEMBL4645801 | — | — | 1 | 5.41 |
| CHEMBL4639838 | — | — | 1 | 5.21 |
| CHEMBL4642086 | — | — | 1 | 5.09 |
| CHEMBL4637690 | — | — | 1 | 5.08 |
| CHEMBL4640039 | — | — | 1 | 4.92 |
| CHEMBL4638576 | — | — | 1 | 4.91 |
| CHEMBL4641656 | — | — | 1 | 4.90 |
| CHEMBL4632510 | — | — | 1 | 4.89 |
| CHEMBL4643091 | — | — | 1 | 4.79 |
| CHEMBL4633227 | — | — | 1 | 4.77 |
| CHEMBL4633680 | — | — | 1 | 4.73 |
| CHEMBL71752 | VINPOCETINE | 2.0 | 1 | 4.72 |
| CHEMBL4635828 | — | — | 1 | 4.72 |
| CHEMBL4640085 | — | — | 1 | 4.71 |
| CHEMBL4639072 | — | — | 1 | 4.61 |
| CHEMBL4646903 | — | — | 1 | 4.61 |
| CHEMBL4636663 | — | — | 1 | 4.58 |
| CHEMBL4638744 | — | — | 1 | 4.58 |
| CHEMBL4633277 | — | — | 1 | 4.52 |
| CHEMBL4649020 | — | — | 1 | 4.51 |
| CHEMBL4644211 | — | — | 1 | 4.51 |
| CHEMBL4642588 | — | — | 1 | 4.48 |
| CHEMBL4643016 | — | — | 1 | 4.42 |
| CHEMBL4643199 | — | — | 1 | 4.40 |
| CHEMBL4638154 | — | — | 1 | 4.39 |
| CHEMBL4649694 | — | — | 1 | 4.37 |
| CHEMBL4633805 | — | — | 1 | 4.32 |
| CHEMBL4644378 | — | — | 1 | 4.31 |
| CHEMBL4648572 | — | — | 1 | 4.31 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4633023 | — | IC50 | = | 3680.0 | nM | 5.43 |
| CHEMBL4645801 | — | IC50 | = | 3860.0 | nM | 5.41 |
| CHEMBL4639838 | — | IC50 | = | 6240.0 | nM | 5.21 |
| CHEMBL4642086 | — | IC50 | = | 8060.0 | nM | 5.09 |
| CHEMBL4637690 | — | IC50 | = | 8420.0 | nM | 5.08 |
| CHEMBL4640039 | — | IC50 | = | 12060.0 | nM | 4.92 |
| CHEMBL4638576 | — | IC50 | = | 12250.0 | nM | 4.91 |
| CHEMBL4641656 | — | IC50 | = | 12480.0 | nM | 4.90 |
| CHEMBL4632510 | — | IC50 | = | 12950.0 | nM | 4.89 |
| CHEMBL4643091 | — | IC50 | = | 16390.0 | nM | 4.79 |
| CHEMBL4633227 | — | IC50 | = | 17030.0 | nM | 4.77 |
| CHEMBL4633680 | — | IC50 | = | 18590.0 | nM | 4.73 |
| CHEMBL71752 | VINPOCETINE | IC50 | = | 18840.0 | nM | 4.72 |
| CHEMBL4635828 | — | IC50 | = | 19040.0 | nM | 4.72 |
| CHEMBL4640085 | — | IC50 | = | 19520.0 | nM | 4.71 |
| CHEMBL4639072 | — | IC50 | = | 24770.0 | nM | 4.61 |
| CHEMBL4646903 | — | IC50 | = | 24320.0 | nM | 4.61 |
| CHEMBL4636663 | — | IC50 | = | 26280.0 | nM | 4.58 |
| CHEMBL4638744 | — | IC50 | = | 26160.0 | nM | 4.58 |
| CHEMBL4633277 | — | IC50 | = | 30090.0 | nM | 4.52 |
| CHEMBL4644211 | — | IC50 | = | 30660.0 | nM | 4.51 |
| CHEMBL4649020 | — | IC50 | = | 30890.0 | nM | 4.51 |
| CHEMBL4642588 | — | IC50 | = | 33240.0 | nM | 4.48 |
| CHEMBL4643016 | — | IC50 | = | 38250.0 | nM | 4.42 |
| CHEMBL4643199 | — | IC50 | = | 39910.0 | nM | 4.40 |
| CHEMBL4638154 | — | IC50 | = | 41100.0 | nM | 4.39 |
| CHEMBL4649694 | — | IC50 | = | 42270.0 | nM | 4.37 |
| CHEMBL4633805 | — | IC50 | = | 47640.0 | nM | 4.32 |
| CHEMBL4644378 | — | IC50 | = | 49290.0 | nM | 4.31 |
| CHEMBL4648572 | — | IC50 | = | 49250.0 | nM | 4.31 |
| CHEMBL4633185 | — | IC50 | = | 50030.0 | nM | 4.30 |
| CHEMBL4640548 | — | IC50 | = | 51970.0 | nM | 4.28 |
| CHEMBL4639361 | — | IC50 | = | 56300.0 | nM | 4.25 |
| CHEMBL4643153 | — | IC50 | = | 58430.0 | nM | 4.23 |
| CHEMBL4643200 | — | IC50 | = | 60170.0 | nM | 4.22 |
| CHEMBL4648949 | — | IC50 | = | 62460.0 | nM | 4.20 |
| CHEMBL4643607 | — | IC50 | = | 64240.0 | nM | 4.19 |
| CHEMBL4635813 | — | IC50 | = | 64080.0 | nM | 4.19 |
| CHEMBL4646556 | — | IC50 | = | 64670.0 | nM | 4.19 |
| CHEMBL4639100 | — | IC50 | = | 65800.0 | nM | 4.18 |
| CHEMBL4649811 | — | IC50 | = | 67350.0 | nM | 4.17 |
| CHEMBL4636207 | — | IC50 | = | 72020.0 | nM | 4.14 |
| CHEMBL4644704 | — | IC50 | = | 74360.0 | nM | 4.13 |