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Assay Detail

CHEMBL4604494

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Binding
Inhibition of Candida albicans ICL assessed as reduction in glyoxylate phenylhydrazone formation using M threo-DL(+)isocitrate as substrate incubated for 30 mins by spectrophotometric method
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Candida albicans
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Isocitrate lyase (CHEMBL5359)
Type SINGLE PROTEIN
Organism Candida albicans

Publication

Isocadiolides A-H: Polybrominated Aromatics from a <i>Synoicum</i> sp. Ascidian.
Bae J, Cho E, Park JS, Won TH, Seo SY, Oh DC, Oh KB, Shin J.
J Nat Prod (2020) 83 : 429 -437
PubMed 31967465 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 4.50 4.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2204151 CADIOLIDE D 1 4.96
CHEMBL451226 1 4.77
CHEMBL2204150 CADIOLIDE C 1 4.77
CHEMBL4634710 1 4.66
CHEMBL2204152 CADIOLIDE E 1 4.57
CHEMBL4647319 1 4.47
CHEMBL4638280 1 4.33
CHEMBL4634031 1 4.31
CHEMBL4648082 1 4.27
CHEMBL2204154 CADIOLIDE B 1 4.21
CHEMBL4639243 1 4.20
CHEMBL4643110 1 -
CHEMBL4645335 1 -
CHEMBL4632741 1 -
CHEMBL4635824 1 -
CHEMBL4075669 1 -
CHEMBL4064483 1 -
CHEMBL511842 RUBROLIDE A 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2204151 CADIOLIDE D IC50 = 11000.0 nM 4.96
CHEMBL451226 IC50 = 17000.0 nM 4.77
CHEMBL2204150 CADIOLIDE C IC50 = 17000.0 nM 4.77
CHEMBL4634710 IC50 = 22000.0 nM 4.66
CHEMBL2204152 CADIOLIDE E IC50 = 27000.0 nM 4.57
CHEMBL4647319 IC50 = 34000.0 nM 4.47
CHEMBL4638280 IC50 = 47000.0 nM 4.33
CHEMBL4634031 IC50 = 49000.0 nM 4.31
CHEMBL4648082 IC50 = 54000.0 nM 4.27
CHEMBL2204154 CADIOLIDE B IC50 = 61000.0 nM 4.21
CHEMBL4639243 IC50 = 63000.0 nM 4.20
CHEMBL4643110 IC50 = 127000.0 nM -
CHEMBL4645335 IC50 > 145000.0 nM -
CHEMBL4632741 IC50 = 104000.0 nM -
CHEMBL4635824 IC50 = 150000.0 nM -
CHEMBL4075669 IC50 > 159000.0 nM -
CHEMBL4064483 IC50 > 159000.0 nM -
CHEMBL511842 RUBROLIDE A IC50 > 216000.0 nM -