Assay Detail
Functional
CHEMBL4604975
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Induction of cell proliferation in human beta cells incubated for 96 hrs by EdU incorporation assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Pancreatic beta cell |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Selective DYRK1A Inhibitor for the Treatment of Type 1 Diabetes: Discovery of 6-Azaindole Derivative GNF2133.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.80 | 6.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4640031 | — | — | 1 | 6.92 |
| CHEMBL4636064 | — | — | 1 | 6.68 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4640031 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4636064 | — | EC50 | = | 210.0 | nM | 6.68 |